The development of the cortex is a delicate balance between proliferation, differentiation, and migration of neural progenitors (NPs). Throughout developmental process, various cellular mechanisms ensure that NPs differentiate into the correct cell subtypes, migrate to their correct regions, and form the...
After their production in the colon, only a small portion is present in the intestine in the unionized form that can cross the epithelial barrier directly, whereas approximately 80–90% of short-chain fatty acids are present in an ionized form and require specific transporters for their ...
1). In their simplest form, deletions and inversions were found to be the most common SV types, while consistent with other PCa studies, we observed a low frequency of insertion events (Additional file 1: Fig. S2). Only 15 tumours (8.3%) presented with at least one insertion, which may...
Open Access also encompasses early dissemination of manuscripts in the form of preprints (articles not yet published in scientific journals). The term “preprint” can refer to either pre-peer-review manuscript or peer-reviewed manuscript before formatting. Hereafter, we use the wording “preprint”...
Almost 36.2% of the participants were IDPs living in camps or informal residency settings. While 12.2% of the participants were illiterate, about 51% had primary, preparatory, or secondary education certificates, and 36.8% had intermediate or university education certificates or higher. Besides, ...
The juvenile form of neuronal ceroid Lipofuscinosis (JNCL) is the most common form within this group of rare lysosomal storage disorders, causing pediatric neurodegeneration. The genetic disorder, which is caused by recessive mutations affecting the CLN3 gene, features progressive vision loss, cognitive...
From the plot, it is clear that MolFinder and MolFinder-local sampled different regions of chemical space compared to the initial data from ZINC15. On the t-SNE plot, MolFinder results form several distinct clusters that are widely spread over chemical space. On the other hand, molecules ...
Oncopeltus is a member of the Hemiptera, the most species-rich hemimetabolous order. Together with the Thysanoptera and, traditionally, the Psocodea, the Hemiptera form the hemipteroid assemblage (or Acercaria), a close outgroup to the Holometabola [2, 3]. All Hemiptera share the same pierci...
of gravity waves. Gravity waves in the stratosphere i.e., SGW have a wind signature with particles moving in a characteristic manner. The discussion in Podglajen et al. [23] and Eichinger et al. [24] is set in the context that the SGW moves a large number of heterogeneous particles. ...
Coupled transcription and translation processes in bacteria cause indiscriminate translation of intact and truncated messenger RNAs, inevitably generating nonfunctional polypeptides. Here, we devised a synthetic protein quality control (ProQC) system that enables translation only when both ends of mRNAs are...