Among integrins, ITGA5 mainly functions as a receptor of fibronectin in form of a heterodimer combined with integrin beta 1 [12]. Recognized as an essential bridge molecule of FAK-ITGA5-Akt axis, ITGA5 is highly expressed in a panel of tumors and results in poor prognosis, through inducing...
41,42]. These methods facilitate the assessment of information flow from one omics layer to another and help elucidate the intricate interplay between various molecular profiles. Recently, advances in statistical modeling and machine learning have enabled more effective...
As a form of non-apoptotic cell death, MPTDN attracted more attention in the development of novel cancer therapies [9]. However, the roles of MPTDN in NSCLC is largely unclear. In this setting, we conducted this integrated analysis to uncover the potential roles of MPTDN-related genes in ...
The clinicopathological significance of MCU was confirmed using real-world BRCA patient tissues and pan-cancer bioinformatics. Additionally, by leveraging data from the Genomics of Drug Sensitivity in Cancer (GDSC) and Cancer Cell Line Encyclopedia (CCLE) repositories, MCU emerged as a validated drug ...
“pRRophetic” and “oncoPredict” R package from the Cancer Therapeutics Response Portal (CTRP) and Genomics of Drug Sensitivity in Cancer (GDSC; http://www.cancerrxgene.org/) were used to predict chemotherapy response for HCC patients. The half-maximum inhibitory concentrations (IC50s) for ...
The performance of GPDRP is demonstrated using the CCLE/GDSC dataset, and it outperforms two recently published models, Precily and GraTransDRP. 3. GPDRP demonstrates the potential to predict unknown drug-cell line pairs. It was utilized to predict the pairs that were missing from the GDSC...
F Pearson’s correlation of GDSC2 drug response (measured by IC50) with each of the four subcutaneous adipocyte subtype scores reveals drug resistance (blue) or sensitivity (red) Full size image The hA4 subtype had a significantly worst prognosis in both the melanoma and breast cancer cohorts....
To inspect the variation induced by the CRISPRcleanR correction, we both inspected sgRNA distributions of defined control sgRNA sets as well as checked for potential correction of sgRNA-level log2 fold changes for regions with known copy number amplification for cell lines included in GDSC1000 data...
Understanding the phenotypic drug response on cancer cell lines plays a vital role in anti-cancer drug discovery and re-purposing. The Genomics of Drug Sensitivity in Cancer (GDSC) database provides open data for researchers in phenotypic screening to bu
Besides, Submap mapping was used to investigate the response of anti-CTLA4/PD1 immunotherapy. Considering the distinction in chemotherapeutic sensitivity in prostate cancer patients, the IC50 values of 138 antitumor drugs in Genomics of Drug Sensitivity in Cancer (GDSC, https://www.cancerrxgene.org/...