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The classical form of chorea occurs in Huntington’s disease, an inherited neurodegenerative disease characterized by striatal atrophy. Chorea is a rather uncommon sign of clinical presentation in neurodegenerative diseases, even though the striatum has been reported as severely affected in FTD [1]. ...
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Tau is the central pathological protein in many types of neurodegenerative disease. Collectively, these diseases are referred to as “tauopathies” due to the key pathological role of tau. Tauopathies can be divided into primary tauopathies including corticobasal degeneration (CBD), Pick’s disease (...
Recent advances in blood-based biomarker discovery are paving the way for simpler, more accessible diagnostic tools that can detect early signs of Alzheimer’s disease (AD). Recent successes in the development of amyloid-targeting immunotherapy approache
aspects of the present invention may take the form of an entirely hardware embodiment, an entirely software embodiment (including firmware, resident software, micro-code, etc.) or an embodiment combining software and hardware aspects that may all generally be referred to herein as a “circuit,”“...
is an innovative antimetabolite agent with immunogenic cell death induction activity for the treatment of chemorefractory crc. limagne et al. found that the combination of ftd/tpi with oxaliplatin can eliminate m2-type tams in ct26 tumor-bearing mice. simultaneous administration of ftd/tpi and ...
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NFL is often normal in clinically pure AD [19] but abnormal in the presence of vascular pathology (for example, small-vessel disease [20], which mainly affects subcortical brain regions). NFL is also elevated in several other pathologic conditions, such as frontotemporal dementia (FTD) [21, ...
[78,79,80]. Female mice also had a more intense increase in hippocampus plaque burden in response to behavioral stress [81]. The initial morphology of amyloid plaques had a compact circular form then became more irregular and diffuse around the subiculum, CA1, and cortex around 12–18 ...