Epilepsy, as a chronic noncommunicable disease with recurrent seizures, may be a marker of deterioration or alteration in other underlying neurological diseases. This study aimed to investigate the relationship of epilepsy with brain function, other common brain disorders, and their underlying mechanisms....
Metastatic brain tumors represent the most prevalent form of intracranial malignancies [1]. Brain metastases manifest in approximately 20–40% of individuals diagnosed with cancer [2, 3]. While any tumor has the potential to spread to the brain, the predominant types include lung cancer, breast ...
5A. Distribution of values for each feature (edge) in the STZ and CTL groups also agreed with the group difference test in the form of graph networks (Fig. 4). For example, in the early timepoints, both methods revealed the STZ group had stronger connectivity between the right hippocampus...
The LOD group also had significantly higher scores on the Short Form Geriatric Depression Scale (SFGDS) (mean = 6.07) (p = 0.002). CGI-S scores reflected this trend, showing a higher severity in the LOD group (p < 0.001). Table 1 Baseline clinical and neurocognitive ...
Written informed consent is obtained from all participants using the approved consent form template from the Committee on Health Research Ethics in the Capital Region of Denmark. Consent for publication Not applicable. No identifying images or personal details of participants are presented here or will...
At low concentrations, methylene blue enters neural mitochondria to form a renewable redox complex that reduces the production of reactive oxygen species and prevents the pathological blockage of MC-I [27, 28]. In rodent models of Alzheimer’s disease, it has been shown to prevent chronic memory...
Additionally, individuals with SCD have an increased presence of the cytotoxic form of Aβ in their plasma compared to normal controls. That is, Aβ in AD pathogenesis exhibits polymorphic patterns, and amyloid-beta oligomer (AβO) is the most cytotoxic soluble form of Aβ that causes neuronal...
(eCRF) and sponsor and, if applicable (i.e., if the principal investigator (PI) is already aware of the dropout because of the PI being in direct contact with the subject, it is not needed to inform the PI in written form), the PI must be informed in written form by the study ...
the participants were also assessed with the Short Form of the Mental Health Continuum (Chinese). The final sample included 65 datasets. Participants who were absent from the MRI scanning (n = 1) or didn’t pass the mental health interview (n = 1) were excluded. The institutional...
In order to test the ability of cells to form colonies, a clonogenic assay was performed. For this purpose, cells were seeded onto a 6-well plate at a density of 1 × 102. The cells were treated with the LPS or/and mitochondria (MT1/MT2). After 7 days of incubation, cells wer...