We have previously shown that neuroinflammation comprising innate and adaptive immune reactions drives axonal damage and neuron loss in the CNS of palmitoyl protein thioesterase 1-deficient (Ppt1−/−) mice, a model of the infantile form of the diseases (CLN1). Therefore, we here explore ...
All publications before August 23, 2022, were identified using the following keywords: “COVID-19”, “SARS-CoV-2”, “Azvudine” and “FNC”. We also manually reviewed the reference lists of relevant articles to identify additional studies. Studies eligible for this meta-analysis met the ...
This mutation induces an aberrant aggregation and accumulation of the mutant htt (mhtt) [1] which causes specific vulnerability to medium-sized spiny neurons [2, 3] and impairs the synaptic connectivity between the cortex and striatum [4, 5]. This degeneration results in choreiform movements, ...
Demonstration of the two-stage approach of SMART.AAn example field of view of the single-cell Nanostring CosMx data in human non-small cell lung cancer.BThe SMART-predicted cell type composition of the example field of view.CA heatmap showing the Pearson correlation coefficients between the pred...
Samples shows the number of biological samples which form the original data set. Neuron Images indicates the total number of individual images containing neurons derived from these samples. Searchable Files indicates the number of CDM images in the library that can be searched. Input Size (GB) ...
One of the essential components of the brain, the white matter (WM), represents areas primarily composed of myelinated axonal fibers [4]. These fibers form the communication pathways between different regions of grey matter (GM) [2, 4, 5]. Traditionally, WM has been associated with the tra...
incubated at -40 °C for 1 h and centrifuged at 12,000 rpm at 4 °C (centrifugal radius of 8.6 cm) for 15 min. The resulting supernatant was transferred into a sample vial for further analysis. Equal volumes of supernatant from all samples were combined to form a quality control (QC)...
This is the first study of the role of the ferroptosis inhibitor ferrostatin-1 in SCI and provides new ideas for future SCI recovery. Ferroptosis was first defined in 2012 as a regulated form of iron-catalyzed necrosis, which occurs through excessive peroxidation of polyunsaturated fatty acids and...
Spinal cord injury (SCI) represents a severe form of neurological trauma resulting from a primary mechanical insult that leads to permanent loss of both motor function and sensory perception [1,2,3]. This primary injury inflicts direct physical damage to the spinal cord, initiating a complex path...
Active PT is characterized by a significant presence of reactivated herpes virus (e.g. HCMV, EBV-1) [4], which can lead to immune suppression and bacterial overgrowth, transforming stable PT into a progressive disease [5]. Alzheimer’s disease (AD), the most prevalent form of dementia, ...