1). We assessed the morphology and properties of the IPN GelMA/chitosan microcarriers (IGMs), as well as the viability, proliferation, and DP signature expression of DPC/PRP-laden IGMs. Finally, DPC/PRP-laden IGMs were mixed with EPC-laden GelMA to form a PRP-loaded DPC/EPC co-cultured ...
Subarachnoid hemorrhage (SAH) represents a form of cerebrovascular event characterized by a notable mortality and morbidity rate. Fibroblast growth factor 21 (FGF21), a versatile hormone predominantly synthesized by the hepatic tissue, has emerged as a promising neuroprotective agent. Nevertheless, the ...
BCMA has a soluble form, sBCMA, derived from direct shedding of the membrane BCMA through γ-secretase activity. sBCMA retains the extracellular domain and a part of the transmembrane region [59]. sBCMA represents a potential biomarker for B cell involvement in human autoimmune diseases such ...
After the endoderm germ layer arises, the definitive endoderm is subsequently surrounded by mesoderm and undergoes a series of morphological changes to form the primitive gut tube, which can be achieved by using FGF10 or keratinocyte growth factor (KGF) (Kroon et al., 2008; Pagliuca et al., ...
The basic idea of the algorithm is to form a low-dimensional vector space by extracting features from a graph by both a breadth-first search and a depth-first search. Node2vec applies two parameters to implement the strategy of random walk. Return Parameter pp controls the probability of the...
into the nucleus and increased c-Myc transcriptional activity. Indeed, c-Myc phosphorylated at S62 associates with the protein partner MAX to form a heterodimer, which, in turns, binds to the E-box elements together with other co-activators and enhancers, driving the transcription of proliferative...
[157]. A recent study also suggests that the increased secretion of FGF-23 by osteocytes is influenced by the elevation of glycerol-3-phosphate in CKD [158]. FGF-23 also inhibits the active form of vitamin D, subsequently impacting PTH elevation [159]. Eventually, the elevations in FGF-...
With this strategy, the authors aimed to mitigate inflammation during systemic protein replacement therapy with human fibroblast growth factor 21 (hFGF21) [160]. Various aliphatic ester prodrugs with differing chain lengths (C5: rofleponide only, C8: budesonide only, C14, C16, and C18) were ...
Skin cancer is a prevalent form of cancer worldwide, and gaining insight into its development is essential for the development of prevention and treatment strategies. The three major types of skin cancer are basal cell carcinoma, squamous cell carcinoma, and melanoma, while merkel cell carcinoma, ...
Three of them form a six-stranded beta-barrel structure that is capped at one end by the other three pairs arranged in a triangular array. The N-terminus of aFGF up to residue Pro19 appears flexible in the structure and does not specifically interact with the rest of the molecule....