Small airway dysfunction (SAD), a hallmark of early lung function abnormality, is a major component of several chronic respiratory disorders. The role of SAD in patients with connective tissue disease-related interstitial lung disease (CTD-ILD) has not b
Idiopathic pulmonary fibrosis (IPF) is a non-neoplastic pulmonary disease that is characterized by the formation of scar tissue within the lungs in the absence of any known provocation. IPF is a rare disease which affects approximately 5 million persons
Inhaled lipopolysaccharide (LPS) induces a dose-dependent, acute neutrophilic response in the airways of healthy volunteers that can be quantified in induced sputum. Chemokines, such as CXCL1 and CXCL8, play an important role in neutrophilic inflammation
(mostly due to fev 1 ), and for 0.8% ( n = 23) of children regarding mental parameters. children with all fifteen health parameters were included, leading to the inclusion of 870 mother–child pairs. characterisation of the exposome a wide range of environmental exposures was assessed ...
Respiratory and QoL assessmentwill utilize the Health-Related Quality of Life measures (HRQL) [92], St. George’s Respiratory Questionnaire (SGRQ), and the Short-form-36 (SF-36). HRQL assesses an individual's perceived physical and mental health. The SGRQ is a standardized, self-administered...
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We planned to use the Newcastle-Ottawa Quality Assessment Form for the analytic observational studies [18], however, we did not identify articles that properly fitted this definition. Data extraction From each study, we selected information regarding study design, date of publication, country of ...
Some EVs derived from other cells are involved in the pathogenesis of COPD Full size image Epithelial cells The three cell types that make up the airway epithelium—basal cells, cupped cells, and ciliated cells—form a basal columnar structure. As the initial line of defense for the respiratory...
Since excess collagen synthesis is a crucial histopathologic feature of RF, other drugs, such as colchicine, penicillamine, statins, and interferon-gamma, may also have the potential to modify the progression of fibrosis. Recently, nintedanib has emerged as a promising form of treatment and ...
Nevertheless, comorbidities were collected in a prospective form using validated questionnaires, and their prevalence was similar to the ones reported in previous cohorts. Thirdly, our study focused on patients with severe airflow obstruction, so our results might be different in other populations....