Birds exhibit a unique asymmetry in terms of gonad development. The female left gonad generates a functional ovary, whereas the right gonad regresses. In males, both left and right gonads would develop into testes. How is this left/right asymmetry establ
we conducted a longitudinal analysis of gene expression in pluripotent stem cells undergoing induced neuronal differentiation. Our analysis uncovers hundreds of AS-NMD events with significant potential to regulate gene expression. Notably, this regulation is significantly overrepresented...
In terms of spatial distribution, they were located near OB cells and, in conjunction with CAFs, form a barrier that blocks T cells and provide a favorable microenvironment for tumor growth. Besides immune cells, tumor cells can also interact with stromal cells. Fibroblasts (CAFs) are the most...
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denote the affine mappings. we prefer to state the affine layers in abstract form, as we can have different types of layer. in this paper, we use \(g_d\) consisting of fully-connected and convolutional layers to reconstruct numerical data and images, respectively. for simplicity, assume ...
S4a). The same phenomenon of tau pathology was observed in the hippocampi of 8-month-old male P301S mice (Additional file 1: Fig. S4b), which expresses the P301S mutant form of hTau. These data indicate that vCA1 exhibits greater sensitivity to AD-like tau pathology than dCA1. Fig....
Diabetic nephropathy (DN) is a complex disease involving the upregulation of many inflammation-related proteins. Alternative polyadenylation (APA), a crucial post-transcriptional regulatory mechanism, has been proven to play vital roles in many inflammat
Following excluding genes missed in any of the datasets (NSNU7 missed in LIRI-JP, RBM15B and MRM1 missed in LICA-FR), a total of 35 writers covering the 5 types of RNA methylated modification were included for further analyses, including 11 Nm writers (CMTR1, CMTR2, FBL, TRMT13, TR...
Ferroptosis is a form of regulated cell death characterised by lipid peroxidation as the terminal endpoint and a requirement for iron. Although it protects against cancer and infection, ferroptosis is also implicated in causing neuronal death in degenerative diseases of the central nervous system (CNS...
processing by Dicer or PIWI proteins [114], and this modification is important for them to form stable structures protected from 3′–5′ truncation and 3′-uridine-triggered degradation (Fig.3) [115,116,117,118]. In addition, Nm is postulated to affect the stability of small RNAs by ...