Mutations in TSC2 are the most common cause of tuberous sclerosis (TSC), a disorder with a high incidence of autism and intellectual disability. TSC2 regulates mRNA translation required for group 1 metabotropic glutamate receptor-dependent synaptic long-
EPSP: 5-enolpyruvyl-shikimate 3-phosphate; FBP: fructose 1,6-biphosphate; G3P: glyceraldehyde 3-phosphate; G6P: glucose 6-phosphate; GLC: glucose; GLY: glycerol; PCA: protocatechuic acid; PEP: phosphoenolpyruvate; l-PHE: l-phenylalanine; PP: pentose phosphate; PPA: phenylpyruvate; PTS: phos...
Finally, the system provides a range of web services that external software systems can use to access up-to-date data from the database. Conclusions BioModels Database has become a recognised reference resource for systems biology. It is being used by the community in a variety of ways; for...
Boxed metabolites were measured in this study. Metabolite abbreviations: PEP, phosphoenolpyruvate; E4P, erythrose-4-phosphate; DAHP, 3-deoxy-D-arabinoheptulosonate-7-phosphate; DHQ, 3-dehydroquinate; DHS, dehydroshikimate; SHIK, shikimate; S3P, shikimate-3-phosphate; EPSP, 5-enolpyruvyl-shikimate-...
Instead of -70 mV the potential difference becomes -40 mV. This depolarization is also called an excitatory postsynaptic potential (EPSP). On the other hand there are neurotransmitters that stop the proliferation of signals. These molecules will cause an outflow of positive ions. Hence a ...
Studies into the mechanisms of corticosteroid action continue to be a rich bed of research, spanning the fields of neuroscience and endocrinology through to immunology and metabolism. However, the vast literature generated, in particular with respect to
Mathematical models of cellular physiological mechanisms often involve random walks on graphs representing transitions within networks of functional states. Schmandt and Galán recently introduced a novel stochastic shielding approximation as a fast, acc
cells Review Exosome in Cardiovascular Diseases: A Complex World Full of Hope Gloria Bellin 1,2 , Chiara Gardin 1,2, Letizia Ferroni 1,2, Juan Carlos Chachques 3, Massimo Rogante 4 , Dinko Mitrecˇic´ 5, Roberto Ferrari 6 and Barbara Zavan 1,6,* 1 Department of Biomedical Sciences...
In each array, four time-to-digital converters (TDCs) are used to quantize the time of photons' arrival, and two address record modules are used to record the column and row information. In this work, Monte Carlo simulations were performed in Matlab in terms of the pile-up effect induced...
Nicoll’s finding that LTP in the Schaffer collateral pathway is associated with a selective increase in the AMPA-type receptor component of the EPSP with little change in the NMDA-type receptor component provided the first evidence that LTP at this synapse is both initiated and expressed ...