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Here we report cryo-EM structures of the full-length Tetrahymena ribozyme in substrate-free and bound states at a resolution of 3.1 Å. Newly resolved peripheral regions form two coaxially stacked helices; these are interconnected by two kissing loop pseudoknots that wrap around the catalytic core...
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e Visualization of TLS-like domain detection of SpaDo and other methods (BayesSpace, SEDR, SpaGCN, Scanpy, and Seurat v4) on 4 RCC spatial transcriptomic datasets Full size image The spatial domains detected by SpaDo form a multi-resolution schema hierarchically, enabling the characterization of...
Recognition Rather Than Recall (recognition = shallow form of retrieval from memory, e.g. a familiar person, recall = deeper retrieval) ”Perfection is achieved, not when there is nothing more to add, but when there is nothing left to take away.”– Antoine de Saint-Exupery Help Users Reco...
If you want to define a different starting point rather than the first section or the first slide of a section, just add the classactiveto the section and slide you want to load first. <divclass="section active">Some section</div> ...
3c). Taking the negatively charged wall of the microchannel as an example, when the liquid contacts the negatively charged wall of the microchannel, the cations in the liquid gather on the wall of the microchannel to form a thin electric double layer (EDL) (0.1 nm-10 nm). Under the ...
Microbiome alterations have been associated with depression, and fecal transfer of depressed patients’ microbiomes is sufficient to enhance despair behaviors in rodents. Yet little is known about the potential mechanisms, whereby microbes modulate depre
The coefficient ag and constant bg form the linear transformation for each gene g. argmina,b∑i(z^g,i−(agzg,i+bg))2 (2) This linear transformation was applied to all bulk RNA-seq profiles to transform them to scnRNA-seq space. This transformation minimizes the deviation between a...
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