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Significant predictors of survival were age, gender and low Eastern Cooperative Oncology Group (ECOG) performance status (p < 0.05). Conclusions: These findings further support the non-inferiority of sublobar resection to lobectomy for stage 1 lung cancer. Additionally, improved perioperative ...
Immunotherapy and radiotherapy play crucial roles in the transformation therapy of locally advanced pancreatic cancer; however, the exploration of effective predictive biomarkers has been unsatisfactory. With the rapid development of radiomics, next-generation sequencing, and machine learning, there is hope ...
In this context, CAR-T-cell therapy, an innovative form of immunotherapy, presents new possibilities for treating T-cell malignancies by specifically engineering a patient’s T cells to recognize and eliminate cancer cells. However, the development of CAR-T-cell therapies targeting T-cell ...
In the continental Antarctica, precipitation occurs almost entirely in the form of snow and is often extremely limited. In some parts of the continent where low atmospheric humidity is typical, much of this snow undergoes sublimation and is lost from terrestrial ecosystems before wetting of the ...
ATTRACTION-5 [92] evaluated the efficacy of nivolumab in combination with chemotherapy as adjuvant therapy for phase III G/GEJC, revealing no significant improvement in relapse-free survival (RFS). However, subgroup analysis indicated benefits from immunotherapy for patients with ECOG 1, postoperative...
The FDA has granted regular approval to blinatumomab (Blincyto) for the treatment of adult and pediatric patients with CD19-positive B-cell precursor acute lymphoblastic leukemia in first or second complete remission with minimal residual disease of at l
(ECOG-PS) of 4, postoperative reconstruction of the upper gastrointestinal tract (excluding Billroth I reconstruction), dysfunction of other organs (American Society of Anesthesiologists physical status classification grade III or IV), life expectancy ≤3 months (this ensures that included patients are ...
DTI is a specialized form of MRI. With the use of DTI, a strong correlation was observed between widespread white matter disconnection, particularly in the fornix, and DOC following severe brain injury [110]. Abnormal structural connections have also been identified within the basal ganglia, fronta...