Oral infection with cysts is the main transmission route of Toxoplasma gondii (T. gondii), which leads to lethal intestinal inflammation. It has been widely recognized that T. gondii infection alters the composition and metabolism of the gut microbiota,
Kerala is a state in south India, appreciated for its education, better health indicators and quality of life. However, there is a proportionately high prevalence of mental health illnesses and suicides reported in the state. It is unclear if there is an
Activities of ATP binding cassette (ABC) proteins are regulated by multiple mechanisms, including protein interactions, phosphorylation, proteolytic processing, and/or oligomerization of the ABC protein itself. Here we present the structure of yeast cadmium factor 1 (Ycf1p) in its mature form following...
125 µL Opti MEM serum reducing medium (Gibco, Grand Island, NY, USA) containing the required amount of siRNA and Lipofectamine 3000 (Thermo Fisher Scientific, Waltham, MA, USA) was added respectively to two centrifuge tubes and incubated at room temperature for 10 min to form a ...
Traditional methods for treating diabetic wounds are limited in effectiveness because of their long healing times, the risk of immune rejection, and susceptibility to infection. Suppressing neutrophil extracellular traps (NETs) is an effective strategy f
Protein lipidation events are a prototypical form of post-translational modification, in which S-palmitoylation exerts multiple effects to dynamically orchestrate the target protein interaction. It involves the reversible attachment of C16 palmitic acid to cysteine residues through thioester bonds [12]. Ab...
Cisplatin (DDP) chemotherapy is commonly used in therapy for non-small cell lung cancer (NSCLC), but increased drug resistance has become a huge obstacle. Baicalin (BA) contributed to the sensitivity of NSCLC to DDP. Here, we aimed to further probe the p
The expression of 2’-5’-oligoadenylate synthetase 1 (OAS1) in lung cancer has been validated in numerous studies. However, the prognostic value of OAS1 expression in lung adenocarcinoma (LUAD) still remains unclear. This study aimed to reveal the progn
Decisive qualifications were previous academic achievements, especially in the field of clinical and health psychology, additional qualifications (e.g., in the form of additional certificates such as “Coaching and Counselling,”“Conversation Management,” etc.), and previous experience in leading ...
Subsequently, cell division cycle 6 (CDC6) and chromatin licensing and DNA replication factor 1 (CDT1) are recruited, and the minichromosome maintenance protein (MCM) 2–7 complex is subsequently loaded onto the replication origin to form the pre-replicative complex (pre-RC) [5]. As CDC6 ...