For example, in breast cancer tissue: (1) the “sulfatase pathway” and “aromatase pathway” are upregulated, thereby providing a steady stream of precursors for estrogen synthesis in the form of inactive steroid sulfates or androgens, respectively, and (2) the reductive 17-β-hydroxysteroid ...
44]. While in other animals, such as ruminants, in which the metabolism of methanogens contributes around 37% of the world’s total anthropogenic methane emissions [27,45], the Methanomassiliicoccales order has been relatively
discussions form the foundation for the proposed definition of the term microbiome, and the set of amendments containing the rules and baselines for microbiome research is described here. Moreover, this article provides an overview on the historical development of microbial research and shows how this...
There is a growing realisation that to fully understand microbial communities it is necessary to resolve them to the level of individual strains [42]. The strain is for many species the fundamental unit of microbiological diversity. This is because two strains of the same species can have very ...
(in absolute value) in the dKD vs. control comparison and a change in the opposite direction in the rescue vs. dKD comparison. For each category of events, we also distinguished two subclasses, depending on whether the 'inclusion' or 'exclusion' form of the event is enhanced when NMD is ...
(A) Distribution of (ϕ,ψ) angles of each residue of the PDZ-bound ligand. Dataset were from PDBsum http://www.ebi.ac.uk/pdbsum/. (B) The orientation of each residue in the side chain of the PDZ ligand in case of a free carboxy-terminal peptide and the internal sequence from ...
Despite its widespread use, RNA-seq is still too laborious and expensive to replace RT-qPCR as the default gene expression analysis method. We present a novel approach, BRB-seq, which uses early multiplexing to produce 3′ cDNA libraries for dozens of sa
Current ligand-based machine learning methods in virtual screening rely heavily on molecular fingerprinting for preprocessing, i.e., explicit description of ligands’ structural and physicochemical properties in a vectorized form. Of particular importance to current methods are the extent to which molecular...
Recent re-sequencing studies have shown that this truncated form of CASP12 confers resistance to sepsis and is predominant across many populations[37–39]. Another non-sense mutation in the SAIF occurred in the OR1B1, which encodes a G-protein coupled olfactory receptor. The OR1B1 SNP leads...
Recent re-sequencing studies have shown that this truncated form of CASP12 confers resistance to sepsis and is predominant across many populations[37–39]. Another non-sense mutation in the SAIF occurred in the OR1B1, which encodes a G-protein coupled olfactory receptor. The OR1B1 SNP leads...