About 32% of pMEIs were within a TAD harboring oncogenes, tumor suppressor genes, or dosage-sensitive genes. In addition, 27.6% of pMEIs form a loop with promoters of those genes within the same TAD (16.3%) or across different TADs (11.3%)....
This form of non-invasive neuroimaging has the potential for the rapid diagnosis of stroke and head trauma, and for the provision of routine monitoring of a wide range of neurological conditions.Similar content being viewed by others Simulation study on the effects of cancellous bone structure in ...
Metasurfaces, artificial 2D structures, have been widely used for the design of various functionalities in optics. Jones matrix, a 2×2 matrix with eight parameters, provides the most complete characterization of the metasurface structures in linear opti
Next, we dissected the relative contribution of CG and non-CG methylation to the distribution of H3K9me2 usingddcc,met1, andmddccmutants. Compared with the wild type, ~11% (type I) and ~30% (type II) of H3K9me2 loci were lost specifically inddccandmet1, respectively; only ~6% (type...
the liver is composed of a variety of cell types that are spatially organized to form distinct functional structures. The most abundant parenchymal cell type in the liver is the hepatocytes which are responsible for majority of the organ functions. The hepatocytes are tightly organized in lobules ...
The human gastrointestinal tract harbors complex and diverse microbes that act as a key factor in maintaining the homeostasis of the intestinal microenvironment [1]. It is estimated that approximately 1013–1014 bacterial cells from more than 1000 different species are present in gut, which form a ...
It has been shown that complete de-condensation of the long Y arm along its euchromatin in Yq11 in human premeiotic male germ cells [3] is required for both sex chromosomes to form the condensed and genetically inactive X–Y pairing structure [4]. Therefore, it has been assumed that the...
we saw that our result took the form of a weighted average. This is also general; under the Brownian motion model, the average of averages will always be a convex combinationwTX=∑i=1nwiXiof the species dataX1, ...,Xn(see Methods). Thus, in defining our notion of an average, we ha...
(2020YFB2206001, 2022ZD0118901), the National Natural Science Foundation of China (62004002, 92064004, 61927901, 62025401, 61834001, 92264203), the 111 Project (B18001) and the NSF-BSF (2020-613). A.M. acknowledges financial support from the Royal Academy of Engineering in the form of a ...
Human pluripotent stem cells (hPSCs) can generate specialized cell lineages that have great potential for regenerative therapies and disease modeling. However, the developmental stage of the lineages generated from conventional hPSC cultures in vitro are