The proteins selected for fusions with CBD were highly reengineered, or ‘artificial’ (= not existing in Nature), which carried condensed functionalisation in the form of concatemers. These were composed of repetitive, bioactive epitopes, oriented in organised head-to-tail fashion, expressed ...
11]. Among them, DNA double-strand breaks (DSB), which are mainly repaired by homologous recombination (HR) and non-homologous end joining (NHEJ), are the most devastating type of DNA damage [12,13].
Moreover, the clone formation of the leucine-rich repeat sequence, including G protein-coupled receptor 5 (Lgr5+) stem cells, was characterized through this model. Additionally, a platform for the functional verification of tumor-driving genes has been created in the form of the organoid model....
a platinum-based chemotherapeutic agent that approved by the US Food and Drug Administration in 1978, is used to treat testicular, ovarian, and bladder cancer. Resistance to cisplatin can arise through several mechanisms, such as reduced intracellular accumulation of the drug...
Although the molecular mechanism underlying this form of cell death is not fully elucidated, it shares common signaling pathways with canonical autophagy. Key regulators driving this process include conserved ubiquitin-fold proteins [e.g., autophagy-related (ATG) proteins]. Among them, the ULK1/2 ...
EcDNA was initially detected in a double-body form, referred to as double minutes [14]. The term ecDNA now refers to those eccDNAs that carry entire or long sequences of coding genes in malignant tumor cells [33], with sizes ranging from 100 kb to 10 Mb [14]. EcDNA lacks centromeres...
Non-small cell lung cancer (NSCLC) is a prevalent form of lung cancer. Patients with advanced NSCLC are currently being treated with various therapies, including traditional radiotherapy, chemotherapy, molecular targeted therapies and immunotherapy. However, a considerable proportion of advance patients wh...
Computer scientists often take problems from chemistry, beat them until their bones have turned to jelly and squash them into a form suitable for a dynamic programming method. The question is, whether these approaches are really the best for problems like docking or RNA folding, where you may ...
The m7G cap structure at the 5' end of mRNA, such as m7GpppX, enhances RNA stability by reducing exonuclease-mediated degradation, thus increasing RNA half-life and maintaining integrity [60]. The m7G cap interacts with eIF4E to form a cap-eIF4E-RNMT complex, which regulates RNA nuclear exp...
Cancer is a major cause of high morbidity and mortality worldwide. Several environmental, genetic and lifestyle factors are associated with the development of cancer in humans and result in suboptimal treatment. The human microbiota has been implicated i