Radiotherapy (RT) stands as a frontline treatment modality in clinical breast oncology, yet challenges like ROS reduction, high toxicity, non-selectivity, and hypoxia hinder efficacy. Additionally, RT administered at different doses can induce varying de
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance, leading to elevated blood sugar levels. Exogenous insulin can counteract the diminished response to insulin and effectively controlling blood glucose levels, the
Microglia-evoked neuroinflammation contributes to neurodegenerative diseases such as multiple sclerosis (MS). Metabolic reprogramming, including changes in polyunsaturated fatty acids (PUFAs), plays a critical role in MS pathophysiology. Previous studies
In our study, we confirm the effectiveness of our proposed approach through an empirical case study involving the utilization of a modified convolutional neural network (CNN) model [4]. This model, known for its capabilities in image recognition tasks, is the backbone of our approach. We pre-p...
Definitions applied in this study can be found in Additional file 1. Specifically, this study provides an overview of studies that have utilised co-creation in co-adapting public health interventions and/or co-creation processes. It seeks to illuminate the co-adaptation processes, whether and ...
2022). As expected, the burden of both diagnosed and undiagnosed diabetes is significant in the cardiac and non-cardiac surgical population. A large prospective observational study evaluating the impact of diabetes on adverse outcomes after surgery, found that about 27% (2047/7565) of the patients...
(GLP-1) agonists, thiazolidinediones, and sulfonylureas also reduced the risk of mortality in diabetic patients with COVID-19 [219,220]. However, some contradictory results have been also reported since administration of DPP-4 inhibitors and sulfonylureas was associated with adverse outcomes and ...
In this study, we investigated the effects of DPP-4 inhibition in obese diabetic db/db mice fed an SL diet or a control diet containing sucrose and oleic acid (SO). We also examined the effects of DPP-4 inhibition in IRS-1-deficient mice fed an SL or SO diet as a model of insulin...
Cisplatin (DDP) chemotherapy is commonly used in therapy for non-small cell lung cancer (NSCLC), but increased drug resistance has become a huge obstacle. Baicalin (BA) contributed to the sensitivity of NSCLC to DDP. Here, we aimed to further probe the p
To assess the feasibility of conducting single-cell CRISPR screens in 3D organoids, we performed a proof-of-concept CROP-seq screen in mouse ICOs (mICOs), isolated from livers of mice expressing spCas9-EGFP at Rosa26 locus (Fig.1a) [25]. mICOs form a self-organized cystic structure in...