4) to reveal that the incorporation of phospholipids (DOPE) into LNP was essential for the delivery of the nucleic acid. Both LNP formulations and mRNA modifications were optimized for in vitro mRNA transfection and subsequently cytotoxic effects on B lymphoma cells. The data paves the way to ...
Pyroptosis, a lytic form of cell death mediated by the gasdermin family, is characterized by cell swelling and membrane rupture. Inducing pyroptosis in cancer cells can enhance antitumor immune responses and is a promising strategy for cancer therapy. Ho
However, we currently lack a product and protocol for the transfection of insect cell lines with long double-stranded RNA (dsRNA). Methods We used agarose gel electrophoresis to determine the capacity of eight TRs to form complexes with long dsRNA. A CellTiter-Glo assay was then used to ...
In the 1980s, critics largely labeled hip-hop a passing fad, refusing to believe that the budding art form would grow into a respected genre. So for hip-hop pioneer Rakim, celebrating the 25th anniversary of his and DJ Eric B.'s 1987 debut album, Paid in Full, is rather humbling....
Chemical compositions of lipid nanoparticles (LNPs): A ionizable cationic lipids (ICLs); B helper lipids; C cholesterol and its derivatives; D PEG-lipids Full size image Component 2: Helper lipids, typical phospholipids like DSPC and DOPE, enhance LNP stability, cellular uptake, and endosomal re...
Will Atkinson's Darkboy, Sideform, Sneijer, Indecent Noise, Mark Sherry, Astrix are all artists on top of the game right now. Non-trance artists that are consistently influential to me would be Mat Zo, Colombo, Matt Lange, SNBRN, Feed Me... but honestly I could spend all day listing...
et al. Smart dope: a self-driving fluidic lab for accelerated development of doped perovskite quantum dots. Adv. Energy Mater. 14, 2302303 (2024). Article CAS Google Scholar Koido, M. et al. Prediction of the cell-type-specific transcription of non-coding RNAs from genome sequences via ...
Formiga ... Self - Brazil 4 episodes, 2015 Ana-Maria Crnogorcevic ... Self - Switzerland 4 episodes, 2015 Teodora Albon ... Self - Referee / ... 4 episodes, 2015 Daniëlle van de Donk ... Self - Netherlands 5 episodes, 2015 Yoon Deok-yeo ... Self - Coach, Sout...
single-chain variable fragments (scFvs), single-domain antibodies (sdAbs), and bispecific antibodies (bsAbs) have demonstrated potential in immunotherapy. BsAbs can form T-cell–bsAb–tumor cell complexes, mediating immune cell-mediated killing [181]. Researchers at CureVac studied mRNA vaccines tar...
ACT, also known as cellular immunotherapy, is a form of treatment that uses the immune cells to eliminate cancer [49]. T cell, NK cell, macrophage cell are three representative ACTs in the current immunotherapy area [212, 213]. The future of ACT seems to be promising. However, despite th...