likely pathogenic, uncertain significance, likely benign, and benign) have been widely used in medical genetics. However, these guidelines are fundamentally constrained in practice owing to their focus upon Mendelian disease genes and their dichotomous classification of variants...
Since 1997, highly pathogenic avian influenza viruses, such as H5N1, have been recognized as a possible pandemic hazard to men and the poultry business. The rapid rate of mutation of H5N1 viruses makes the whole process of designing vaccines extremely challenging. Here, we used an in silico app...
The parent completed the family and medical information form, which included general questions about the caretaker and child demographics as well as disease-specific questions regarding the child. Parents reported whether their child exercised “sometimes or regularly” (greater than or equal to two tim...
This doctrine was born of pure shimmering hubris as it sought to build atop the pre-existent petrodollar form a superstructure of such towering, Babelian ‘managerialism’ that authentic supply/demand signals would forever languish in a state of permanent estrangement beneath a will-to-power complex...
The results suggest that MeCP2 is part of a complex that is located at the promoter regions of these genes in normal brain and that this complex may not form in brain of Mecp2 tm1.1Bird mutant mice. Figure 6 Chromatin immunoprecipitation (ChIP) analysis of differentially expressed genes. ...
of neurofibromin is its role in tightly regulating cellular levels of activated RAS proteins. All RAS proteins exist in two cellular states, the majority being found in their inactive GDP-bound form, with only a very small fraction present in their metabolically active GTP-bound form. Only in...
Single nucleotide variants (SNVs) in intronic regions have yet to be systematically investigated for their disease-causing potential. Using known pathogenic and neutral intronic SNVs (iSNVs) as training data, we develop the RegSNPs-intron algorithm based
'Wikification of GIS by the masses' is a phrase-term first coined by Kamel Boulos in 2005, two years earlier than Goodchild's term 'Volunteered Geographic Information'. Six years later (2005-2011), OpenStreetMap and Google Earth (GE) are now full-fledged
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The mechanistic details of most disease-causing mutations remain poorly explored within the context of regulatory networks. We present a high-resolution three-dimensional integrated regulatory network (iRegNet3D) in the form of a web tool, where we resol