For instance, elevated interstitial pressure within the tumor may restrict the permeation of drugs from vasculature to tumor tissue; insufficient lymphatic drainage could lead to a reduction in drug retention within the tumor; and the tumor stroma may form a physical barrier that impedes the ...
Consequently, the maximum tolerated dose (MTD) of DMOT4039A was confirmed to be 2.4 mg/kg. At this dose, the median PFS for patients with ovarian cancer was noted to be 4.9 months [46]. DMOT4039A demonstrated evidence of anti-tumor activity with a tolerable safety profile and exhibited ...
The emerging potential of nanotechnology is ushering in fresh opportunities in the field of diagnosing, treating, and ultimately curing human diseases. The utilization of nanocarriers or nano-formulations for AD therapy brings several advantages, including the ability to bypass hepatic metabolism, lower d...
non-fibrillar accumulation of p-τ in the perikaryon of neurons) [36]. Precursor lesions in the form of initial cytoplasmic and neuropil τ have been described but it is not yet clear whether these lesions represent a still physiological, reversible status...
Triple-negative breast cancer (TNBC), a highly aggressive subtype of breast cancer, negatively expresses estrogen receptor, progesterone receptor, and the human epidermal growth factor receptor 2 (HER2). Although chemotherapy is the main form of treatment for patients with TNBC, the effectiveness of ...
The MVDR beamformer has a slightly more complicated form than the DS beamformer. It involves the estimation of the noise covariance matrix in the estimation of the optimal weight vector. The optimal weight vector minimizes the total output signal power at each frequency bin while constraining the...
Early preclinical evidence provided the rationale for programmed cell death 1 (PD-1) and programmed death ligand 1 (PD-L1) blockade as a potential form of cancer immunotherapy given that activation of the PD-1/PD-L1 axis putatively served as a mechanism for tumor evasion of host tumor antigen...
These studies form the points of reference for the discussion and assessments of the processes and emerging outcomes from the application of AFR. The action research approach We used a staged approach to the introduction of the AFR concept in each study district. The action research process ...
However, in women, the longitudinal cells do not form an internal sphincter. Oswald et al. found that although the growth of the bladder neck increased proportional to the gestational age, males (20–40-week gestation) have a denser internal sphincter and a significantly narrower bladder neck ...
In the CNS, astrocytes numerically surpass microglia and form a dense surveying network readily responding to changes affecting milieu of the nervous tissue. Examining early stage of Aβ deposition in 6-month-old mice, we found that the numerical density of nascent plaques and the subset of ...