The female reproductive cycle is multistage; it commences with the onset of the menstrual cycle (menarche) and culminates in menopause [1]. During female fetal life, primary oocytes with their surrounding somatic or granulosa cells form “primary follicles”. During puberty, under the influence of...
Visibility of System Status The Match Between The System And The Real World Every system should have a clear emergency exit Don't forget that people spend 90% of their time interacting with other apps Recognition Rather Than Recall (recognition = shallow form of retrieval from memory, e.g. a...
It is a congenital deformity of the external genitalia, defined as abnormal positioning of the urethral opening caused by abnormal development of the urethral fold and the ventral foreskin of the penis [1]. This condition occurs during fetal development, when the urethral opening does not form ...
Initial screening of titles and abstracts from the original search was first conducted independently by two reviewers with experience in mental health research and in conducting systematic review and meta-analysis (DHH and WS). Next, full texts of relevant studies were reviewed, and only those satis...
Recognition Rather Than Recall (recognition = shallow form of retrieval from memory, e.g. a familiar person, recall = deeper retrieval) ”Perfection is achieved, not when there is nothing more to add, but when there is nothing left to take away.”– Antoine de Saint-Exupery Help Users Reco...
These genes form a distinct cluster because of the relative absence of expression from neutrophils, consistent with their known relative low rates of active protein synthesis and the acute regulation of translation during myeloid differentiation[30]. Also situated in the same neighbourhood of the graph...
In addition to its essential role in bone health, calcium, in the form of ionized calcium, is critical in a number of physiological functions, including neuronal function, muscle contraction, clotting, and intracellular signaling. Organisms cannot survive when such functions are compromised. As such...
The main merit of this work lies in the integrated implementation of the methods in the form of a very robust and user-friendly program, which is easily used by biologists. The implementation goes well beyond the hastily written "proof of concept" implementations that so often accompany method ...
(NICD), the COOH-terminal portion of the receptor, is released and translocated to the nucleus to form a complex with the transcription factor CSL (also known as RBP-JK) and the transcriptional coactivator mastermind-like 1 [48]. The ultimate complex targets the hairy and enhancer of split ...
Without Shh, Gli3 has a repressor form (Gli3R). When Shh binds to Ptch and activates Smo, Smo converts Gli3R into an activated form (Gli3A). So, Gli3 works as a transcriptional factor with a dual function. The ratio of Gli3R/Gli3A is directly related to the control of several...