The cell is the basic building block of life. Tissues are composed of many heterogeneous cells, usually numbering in the millions to billions. Each cell occupies a unique location and plays specific roles that contribute to the physiological functions of the tissue. These functions include adhesion,...
In response to drought stress (DS), plants undergo complex processes that entail significant transcriptome reprogramming. However, the intricate relationship between the dynamic alterations in the three-dimensional (3D) genome and the modulation of gene
Epilepsy is a recurring neurological disease caused by the abnormal electrical activity in the brain. This disease has caused about 50 new cases in 100,000 populations every year with the clinical manifestations of awareness loss, bruising, and mobility
Uveal melanoma (UM) is a rare and deadly eye cancer with high metastatic potential. Despite the predominance of malignant cells within the tumor microenvironment, the heterogeneity and underlying molecular features remain to be fully characterized. We an
The discovery of new forms of ICD and their roles in immunity and tumorigenesis have promoted the renewal of anti-tumor treatment strategies. Pyroptosis is a newly characterized form of ICD and has gradually emerged as a great opportunity to improve the efficacy of cancer immune therapy. Pyroptosis...
Such activation enables the unfolding of ROCK and its transition to the active form, with numerous targets, including substrates involved in cell adhesion, neurite retraction, phagocytosis, apoptosis, cell migration, etc. More recently, the potential roles of ROCKis in neuroprotection (maintenance of ...
In recent years, material synthesis technology is developing faster and faster, inorganic materials with different elements and different functional properties are expected to be applied in biology and medicine, including PSs for PDT [1]. Cu ions, a common inorganic metal material, are often used ...
result in the mitochondrial accumulation of highly reactive superoxide radicals, which when present in excess can react with mitochondrial nitric oxide to produce peroxynitrite, a reactive nitrogen species (RNS) [24] and a potent oxidant that can modify proteins to form 3-nitrotyrosine (3 NT) [25...
Mercury (Hg) is highly toxic and has the potential to cause severe health problems for humans and foraging animals when transported into edible plant parts. Soil rhizobia that form symbiosis with legumes may possess mechanisms to prevent heavy metal tran
(alexandra. lusser@i-med.ac.at) Embryonic stem cell differentiation requires full length Chd1 Paolo Piatti1, Chin Yan Lim2, Roxana Nat3, Andreas Villunger4, Stephan Geley5, Yan Ting Shue2, Claudia Soratroi4, Markus Moser6 & Alexandra Lusser1 1Division of Molecular Biology, Biocenter, ...