Reis G, Dos Santos Moreira-Silva EA, Silva DCM, Thabane L, Milagres AC, Ferreira TS, et al. Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19: the TOGETHER randomised, platform clinical trial. Lancet Glob Health. 2022;10(...
However, there are few studies on EVs secreted by other cells involved in the pathological process of DR, and further research is still needed. Diabetic Cardiomyopathy (DCM) DCM is a kind of cardiomyopathy that is not explained exactly by hypertension, ischemic cardiomyopathy, or other common ...
a form of helping in which people actively seek out opportunities to assist others in need, make considerable and continuing commitments to provide assistance, and sustain these commitments over extended periods of time, often at considerable personal cost.” This definition underscores the enduring ...
and these patients are referred to specialized clinics. Dogs with DCM form both a valuable non-human patient cohort and an essential natural model organism for human DCM with similar disease etiology and progression, clinical signs, sex predisposition, prognosis, and response to medical treatment stra...
Pemphigus is a rare autoimmune herpetic disease that affects the skin and mucous membranes and poses a serious threat to human health. PV is the most common and severe form of pemphigus [85]. The pathogenesis of PV involves anti-desmoglein (Dsg) antibodies that disrupt the epidermal cell juncti...
One of the leading current trends in technology is the miniaturization of devices to the microscale and nanoscale. The highly advanced approaches are based on biological systems, subjected to bioengineering using chemical, enzymatic and recombinant metho
Genome editing has also been used to correct DCM-causing mutations. In addition to previous studies using hiPSC-CMs showing that truncated titin (TTNtv) mutations are the most common causes of DCM [183,184,185], recently, the pathological mechanisms of TTNtv-associated DCM have been highlighted...
in cartilage are chondroblasts, which have the ability to proliferate and secrete ECM and further differentiate into mature cells, such as chondrocytes. ECM is composed of water, collagen, proteoglycan, and other components, which mainly form the tissue structure of articular cartilage. Furthermore,...
Let us for example consider a microarray experiment where the objective of the study is to compare the differentially expressed genes from heart failure tissue between cases and controls where the cases are patients with coronary artery disease (CAD) or dilated cardiomyopathy (DCM) and the controls...
Triple negative breast cancer (TNBC) is an aggressive tumor with extremely high mortality that results from its lack of effective therapeutic targets. As an adhesion molecule related to tumorigenesis and tumor metastasis, cluster of differentiation-44 (a