Classification underlies many scientific enterprises where it provides predictive capability based purely on information about attributes of a given set of entities. Classification has been a fundamental step in devising and structuring knowledge in chemistry [1], as illustrated through several classification...
Compared to the other two methods, OCT embedding is suitable for tissue samples that require rapid processing, particularly for frozen tissue samples, immunohistochemical staining, and in situ hybridization experiments. This is because it can preserve the antigenicity of proteins and the integrity of RN...
Gram negative bacteria exhibit two distinct pathways for BEVs biogenesis, which lead to the formation of different types of vesicles. As shown on the left side of the dashed line in Fig.1. The process of explosive cell lysis corresponds to the production of outer-inner membrane vesicles (OIMV...
www.nature.com/scientificreports OPEN Full use of factors promoting catalytic performance of chitosan supported manganese porphyrin Lin‑Qiang Mo1,2,5, Xian‑Fei Huang3,5, Gao‑Cai Wang4, Guan Huang1* & Peng Liu1 In order to make full use of the impact of internal ...
I think it shoul dbe in 0, because I clicked pay with it saying 49 (since the previous window had said they would apply the discount on the checkout) and they took my 49$ with no discount anyways 🙁 Reply Nuria 4/13/2020 at 4:45pm If it still says 49 dollars what you need ...
Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that utilize the ubiquitin proteasome system (UPS) to degrade proteins of interest (POI). PROTACs are potentially superior to conventional small molecule inhibitors (SMIs) be
Structure elucidation of unknown small molecules by mass spectrometry is a challenge despite advances in instrumentation. The first crucial step is to obtain correct elemental compositions. In order to automatically constrain the thousands of possible candidate structures, rules need to be developed to se...
Hook effect of PROTAC The bifunctional molecule (“B”) interacts with its two substrates (“A” and “C”), forming “A-B-C” ternary complex to exert its biological functions. When the concentration of “B” exceeds a certain range, “B” prefers to form “A-B” and “B-C” bina...
Transcription factors (TFs) control transcription by binding to specific regions of DNA called transcription factor binding sites (TFBSs). The identification of TFBSs is a crucial problem in computational biology and includes the subtask of predicting th
Its leaf, stem and bud are extremely compact in form of a round-shaped frond, resembling a single leaf. Large numbers of Spirodela plants can be maintained like cell cultures under totally controlled medium and environmental conditions. They reproduce vegetatively through budding of fronds (growth...