Mycosis fungoides (MF) is the most common type of cutaneous T cell lymphoma. As the early clinical manifestations of MF are non-specific (e.g., erythema or plaques), it is often misdiagnosed as inflammatory skin conditions (e.g., atopic dermatitis, psori
Adipose-derived stem cells (ADSCs) have been extensively used in preclinical and clinical trials for treating various diseases. However, the differences between ADSCs from lean individuals (L-ADSCs) and those from obese individuals (O-ADSCs) have not bee
The growing prevalence of inflammatory bowel disease (IBD) has encouraged research efforts, which have contributed to gradual improvements in our understanding of IBD diagnosis and therapeutic approaches. The pathogenesis of IBD has not been fully elucid
Inflammation is a key pathological feature of many diseases, disrupting normal tissue structure and resulting in irreversible damage. Despite the need for effective inflammation control, current treatments, including stem cell therapies, remain insuffici
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(Additional file7: Figure S4). Furthermore, the observed mass of the recombinant SA8 was 6 Da less than that of the reduced form of the peptide (MH+m/z = 5444.23 Da), indicating formation of three disulphide bonds. LC–MS/MS analysis of pepsin-digested SA8 revealed the disulphide-...
1. The first stage is endocytosis of the cytoplasmic membrane, which carries the material on the membrane and around the cell to form the early sorting endosome. In the second stage, the early sorting endosome gradually progresses to the late sorting endosome. Furthermore, the endosomal limiting...
Taohong Siwu Decoction (THSWD) is a prescription which included in the “List of Ancient Classic Prescriptions (First Batch)” issued by the National Administration of Traditional Chinese Medicine (TCM) and the National Medical Products Administration of the People’s Republic of China. THSWD is...
The switch to osteoclast differentiation requires expression in osteoclast precursors (OCPs) of c-Fos, a RANKL activated transcription factor [3]. To resorb bone effectively, osteoclasts attach themselves firmly to the bone surface using specialized actin-rich podosomes, which they use to form tightly...
Accumulating evidence indicates that the TME plays a critical role in CRC development, progression and metastasis [4, 5]. For example, Shang et al. found that VEGFR2 antibody fused with a mutated form of IFN-α could effectively modulate the TME of CRC, producing anti-tumor and anti-...