Drug induced bile duct injury is a frequently observed clinical problem leading to a wide range of pathological features. During the past decades, several agents have been identified with various postulated mechanisms of bile duct damage, however, mostly
Patients in the pre-dementia stage, such as those with mild cognitive impairment (MCI), are expected to derive more benefit from potential treatments [2]. However, it is important to note that the causes and outcomes of MCI vary widely, and not all individuals with MCI will inevitably ...
In addition, transport and diffusion of ions by the BBB and CP epithelium are involved in the formation of fluid, the ISF and CSF, respectively, so the last part of this review discusses molecular biology of ion transporters/exchangers and ion channels in the brain endothelial and CP ...
To develop ChromGene, we first noted that a mixture of HMMs can be equivalently expressed using a single, specially constructed HMM. In this single HMM, there is a “dummy state” that is associated with the emission of a “dummy mark,” which is only present before or after genes and t...
Mantle cell lymphoma (MCL) is a subtype of Non-Hodgkin lymphoma (NHL) of mature B-cells characterized by translocation, which is typically due to excess expression of Cyclin D1. Although with the progress in our knowledge of the causes for MCL and availa
Tissue-resident macrophages and recruited macrophages play pivotal roles in innate immunity and the maintenance of brain homeostasis. Investigating the involvement of these macrophage populations in eliciting pathological changes associated with neurodeg
Immunotherapies, specifically immune checkpoint inhibitors (ICIs) such as programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand 1(PD-L1), provided a significant advance in cancer treatment [1]. CAR-T cell therapy is a novel form of immunotherapy that employs genetic engineer...
The growing prevalence of inflammatory bowel disease (IBD) has encouraged research efforts, which have contributed to gradual improvements in our understanding of IBD diagnosis and therapeutic approaches. The pathogenesis of IBD has not been fully elucid
N1-methyladenosine (m1A) is a post-transcriptionally modified RNA molecule that plays a pivotal role in the regulation of various biological functions and activities. Especially in cancer cell invasion, proliferation and cell cycle regulation. Over recen
To summarize the mechanisms and pathophysiological features of ALI after burn. To classify the targets for the treatment of ALI. Describe the types of nanomedicines used to treat ALI. These findings suggest the prospects and outlook for nanomaterial-targ