The shisham tree (Dalbergia sissoo) is a keystone hardwood species of South Asia, highly valued in economic value in forestry, agroforestry, and landscape horticulture due to its durable, fragrant, and decay-resistant wood. However, shisham's health on b
MiRNAs typically consist of approximately 20–24 nucleotides and regulate the function of target messenger RNA (mRNA) at the post-transcriptional stage by precisely matching the 3’ non-coding region of the target mRNA [1]. In the realm of human RNAs, aside from mRNA, which is responsible for...
the network architecture and data/modeling infrastructure, training, testing setup, and statistical analysis. ww, xkl and pd wrote the manuscript. ww provided clinical expertise and guidance on the study design. cqy, ykz, ch, szl, wbd and xll created the datasets, interpreted the data, and ...
form, that is based on (or derived from) the Work and for which the editorial revisions, annotations, elaborations, or other modifications represent, as a whole, an original work of authorship. For the purposes of this License, Derivative Works shall not include works that remain separable from...
of the human prion protein exhibit a number of hydrophobic cavities in the well-folded core (amino acids 125 to 231) but the full length prion protein may also transiently form new cavities when the presumably disordered N-terminus gets in contact with the compactly folded part of the protein...
assays in this study. NPs would adsorb proteins from cell culture medium to form protein corona on particles, which might affect the biological absorption, internalization, and toxicity of PS-NPs [60]. Therefore, serum-free cell culture was used in these assays to exclude the effects of protein...
A further list and descriptions of these risks, uncertainties and other factors can be found in Johnson & Johnson’s Annual Report on Form 10-K for the fiscal year ended January 1, 2023, including in the sections captioned “Cautionary Note Regarding Forward-Looking Statements” and “Item 1A...
The latter impairment is the most serious form of DNA damage [135]. A disfigured genome is the stimulus that initiates DNA damage response (DDR) processes [136,137]. These consist of a series of complex events that heal the DNA lesions. When the damage is highly deleterious, however, it ...
Also the hydrodynamic diameter of particles, or secondary particle size, may be of importance with respect to particle neurotoxicity. While smaller particles may seem more neurotoxic, they are also more likely to cluster together and form aggregates. While aggregation increases (secondary) particle siz...