The popular neighbor-joining (NJ) algorithm used in phylogenetics is a greedy algorithm for finding the balanced minimum evolution (BME) tree associated to a dissimilarity map. From this point of view, NJ is "optimal" when the algorithm outputs the tree
, with the exact relative performance dependening on the particular system. both variants provide an efficient tool for the computational engineering of ligands and proteins. methods effective energy function the effective free energy function we used in our calculations takes the following form: ...
Formally, the FDA defines a CQA as “a physical, chemical, biological, or microbiological property or characteristic that should be within an appropriate limit, range, or distribution to ensure the desired product quality [31].” Given that no such CQAs for MSC products designed to treat ARDS ...
Quinoa (Chenopodium quinoaWilld.,2n = 4x = 36) is an annual dicotyledonous and often cross-pollinating plant of the Amaranth family that has been cultivated for over 5000 years. It is the traditional food of the Inca indigenous humans, known as the “golden grain” and the “mothe...
Gene expression levels in a given cell can be influenced by different factors, namely pharmacological or medical treatments. The response to a given stimulus is usually different for different genes and may depend on time. One of the goals of modern molecular biology is the high-throughput identif...
Lacking scientific understanding about interdependencies of critical process parameters (CPP), critical quality attributes (CQA) and key performance parameters (KPP), manufacturers conventionally stick to well-established complex media fermentation protocols to ensure growth and productivity, and thus fail at...
to solve an overdetermined set of equations whose coefficients are noisy. The CTLS is a natural extension of TLS to the case where the noise components of the coefficients are correlated, as is usually the case with time-series measurements of concentrations and expression profiles in gene ...
at different operation points, the linearization of nonlinear stochastic regulatory network of equation (4) will be of the form in equation (3), i.e., at an operation point x = x 0 , n = ∂ n ( x ) ∂ x | x = x 0 mathtype@mtef@5@5@+=feaafiart1ev1aaatcvaufkttlearuwrp...
NMR structure of trp-cage protein 1l2y. Labels on graph mark amino acids(AAs). AA2 to AA7 roughly form an alpha-helix. AA2 to AA19 form a ring-type structure. In particular, AA2 to AA5 and AA16 to AA19 form the "neck" of this ring. Full size image The RMSD for a conforma...
and provides the model output in different formats (C MEX, MATLAB,Mathematicaand SBML) as ready-to-run simulation files. ALC also provides additional documentation files that simplify the publication or presentation of the models. The tool can be used offline or via a form on the ALC website...