They include the Cdc45 gene, a component of the CMG (CDC45-MCMs-GINS) complex, whose expression is related to cycle progression. In case of loss of the expression levels, Cdc45 determines the inhibition of DNA replication and G1-phase arrest with consequently inhibition of the cell ...
Graben and host structures have been formed as a result of the Pacific Plate subduction. These grabens and horst form basins along the strike of the Japan Trench during oblique subduction (e.g., Kobayashi et al. 1998). Sedimentary sequences infill a few to several km-width narrow basins, ...
Visual prognosis of Disciform Degeneration in Myopia. Ophthalmology. 1983;90(8):923–6. Article CAS PubMed Google Scholar Tabandeh H, Flynn HW, Scott IU, et al. Visual acuity outcomes of patients 50 years of age and older with high myopia and untreated choroidal neovascularization. ...
Plants take up nutrients from the soil for growth through the root system and return them to the soil in the form of apoplastic material, which is broken down by microorganisms into various types of nutrients. Therefore, investigating the linkages between soil nutrients, microbes, and the root ...
The soluble form of these molecules can further enhance immune cell activation and facilitate extravasation during inflammation. ICAM-1 and VCAM-1 are expressed predominantly by endothelial cells (although low levels of ICAM-1 are also expressed in some immune cells) and play a critical role in ...
To fully understand the size and demographic distribution of the high-risk population, and to consider interventions that could assist all groups in that population, it would be necessary pursue some form of population-based research. One approach might involve a comprehensive set of regional, popula...
CMG901 CMG901 is a CLDN 18.2-targeting ADC that consists of three components: a monoclonal antibody targeting CLDN18.2, a cleavable linker and a potent cytotoxic payload (MMAE). CMG901 binds to Claudin 18.2-positive cells via its monoclonal antibody portion. After binding, CMG901 is internalize...
to assemble the CMG complex (Cdc45-MCM2-7-GINS), which is the active form of the replicative helicase [77,78]. It is believed that Mcm10 is also required for DNA replication initiation and for the loading of the DNA polymerase α-primase complex [79,80,81]. Once activated, helicase ...
Data were extracted from included studies using a pilot extraction form in the Google Forms platform form. It included study characteristics (e.g., design, sample, location), sex/gender of first and last author, outcome, results, and the items in the assessment tool. Data extraction for each...
Formation of CNPs nanoparticles and synergistic anti-tumor immunotherapy strategy based on vaccine, anti-PD1 antibody and CD16 CAR-T cells. A CpG ODN was encapsulated by CMG and PS to form CpG ODN –loaded nanoparticle (CNPs) through self-assembly approach. Vaccines were generated by mixing CNPs...