Aging is associated with the development of a chronic low-grade inflammatory phenotype (CLIP) [93]. Such CLIP may be induced by chronic viral infections, among others. Cellular senescence may also contribute to CLIP as senescent cells circulate in the tissues through the body. They secrete a ...
Part of this problem may be related to insufficient training of investigators regarding A&A in laboratory animals [2]. For example, there is a common myth among some researchers assuming anesthesia is equivalent to analgesia. Accordingly, some papers may report using a hypnotic drug (pentobarbital)...
Although the intact form of CD6 is the most abundant in T cells, an isoform lacking d3 (CD6∆d3) is transiently expressed on activated T cells. Still, the precise character of the signaling transduced by CD6, whether costimulatory or inhibitory, and the influence of its ectodomain on ...
HITS-CLIP: High-Throughput Sequencing of RNA Isolated by Crosslinking Immunoprecipitation Procedure HOP: Head of Pancreas MET: Mesenchymal-to-Epithelial Transition miR: microRNA NPV: Negative Predictive Value NTA: Nanoparticle Tracking Analysis PDAC: Pancreatic Ductal Adenocarcinoma PPV: Positive ...
We conducted a retrospective observational study to explore the potential application of impulse oscillometry (IOS) as an alternative to high-resolution computed tomography (HRCT) for detecting pulmonary involvement in patients with rheumatoid arthritis (RA) because clinically evident interstitial lung disease...
The exon junction complex (EJC) is a dynamic multi-protein complex deposited onto nuclear spliced mRNAs upstream of exon-exon junctions. The four core proteins, eIF4A3, Magoh, Y14 and MLN51, are stably bound to mRNAs during their lifecycle, serving as a
Ii is cleaved initially to the so-called CLIP fragment, with CLIP later being displaced by high-affinity peptides. The peptide – MHC class II protein complex is translocated to the cell surface, where it is recognized by CD4+ T cells. Peptides binding to MHC class II vary in length ...
Cardiovascular risk and mortality in end-stage renal disease patients undergoing dialysis: sleep study, pulmonary function, respiratory mechanics, upper airway collapsibility, autonomic nervous activity, depression, anxiety, stress and quality of life: a prospective, double blind, randomized controlled clinic...
Removal of adapter sequences and sequence quality was confirmed using the FastQC programme [30]. Low-quality regions of reads were trimmed using Trimmomatic v 0.39 [31] with the following settings: ILLUMINACLIP:./Adaptors.fa:2:30:10 LEADING:3 TRAILING:3 SLIDINGWINDOW: 4:28 MINLEN:36 where ...
De-multiplexed sequencing reads belonging to LUND1 were processed in silico with the EAGER pipeline (v.1.92) [24]. ClipAndMerge was used for adapter removal, fragment length filtering (minimum sequence length, 30 bp), and base sequence quality filtering (minimum base quality, 20). MALT v....