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The Limb Girdle Muscular Dystrophies (LGMDs) are characterized by progressive weakness of the shoulder and hip girdle muscles as a result of over 30 different genetic mutations. This study is designed to develop clinical outcome assessments across the group of disorders. Methods/design The primary ...
it remains one of the most pervasive and life-threatening diseases, with steadily increasing mortality rates [1,2]. Cancer complexity is largely influenced by the tumor microenvironment (TME), which is characterized by abnormal
transformation or translation of a Source form, including but not limited to compiled object code, generated documentation, and conversions to other media types. "Work" shall mean the work of authorship, whether in Source or Object form, made available under the License, as indicated by a copyri...
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The increasing number of open-access ontologies and their key role in several applications such as decision-support systems highlight the importance of their validation. Human expertise is crucial for the validation of ontologies from a domain point-of-view. However, the growing number of ontologies...
Specifically, consent will be sought for samples to be shipped to laboratories outside the country and for genetic testing of samples. A separate consent form will be used for this, with participants able to decline even if they consented to participation in the trial....
and accelerating grain filling (Gao et al.2021). The other protein is Chang Li Geng1-1 (CLG1-1), an E3 ubiquitin ligase, which can ubiquitinate and mediate the degradation of GS3, thus changing G protein signaling and regulating the grain length (Yang et al.2021b)....
NEPC is rarely diagnosed de novo in its pure form (small cell or large cell prostate cancer, < 2% of first diagnoses) [10], but about 10-17% of patients with metastatic CRPC have been reported to progress with t-NEPC when treated with NHA [11]. Increased therapeutic pressure on the...
(loops A-F) that form the ligand binding site [31]; (b) the dicysteine-loop (cys-loop) consisting of two disulphide bond-forming cysteines separated by 13 amino acid residues; (c) four transmembrane regions (TM1–4), the second of which (TM2) contributes most of the channel lining ...