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it remains one of the most pervasive and life-threatening diseases, with steadily increasing mortality rates [1,2]. Cancer complexity is largely influenced by the tumor microenvironment (TME), which is characterized by abnormal
transformation or translation of a Source form, including but not limited to compiled object code, generated documentation, and conversions to other media types. "Work" shall mean the work of authorship, whether in Source or Object form, made available under the License, as indicated by a copyri...
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NEPC is rarely diagnosed de novo in its pure form (small cell or large cell prostate cancer, < 2% of first diagnoses) [10], but about 10-17% of patients with metastatic CRPC have been reported to progress with t-NEPC when treated with NHA [11]. Increased therapeutic pressure on the...
(loops A-F) that form the ligand binding site [31]; (b) the dicysteine-loop (cys-loop) consisting of two disulphide bond-forming cysteines separated by 13 amino acid residues; (c) four transmembrane regions (TM1–4), the second of which (TM2) contributes most of the channel lining ...
They also often form the backbone of evidence-based decision-making processes, as well as infectious disease (ID) public health policies that deal with prioritisation, and the planning of intervention measures and healthcare services [1]. However, there are limitations associated with the use of ...
The increasing number of open-access ontologies and their key role in several applications such as decision-support systems highlight the importance of their validation. Human expertise is crucial for the validation of ontologies from a domain point-of-view. However, the growing number of ontologies...
of expression patterns because their products form pathways. The glycolytic pathway is located in the cytosol and consists of a sequence of ten steps catalyzed by 22 different gene products, some of which are isozymes. The product of glycolysis (pyruvate) serves as starting material for the ...
renewable technologies is now important. Unlike fossil fuels, which take millions of years to form, at present usage rates, the fossil fuel era will last only approximately 400 years [84]. Investing in renewables is thus crucial, as future generations will witness the end of finite fossil ...