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The Rho GTPases A, B and C proteins, members of the Rho family whose activity is regulated by GDP/GTP cycling, function in many cellular pathways controlling proliferation and have recently been implicated in tumorigenesis. Although overexpression of Rho
While the basic neural systems involved in positive and negative reinforcement, are similar in males and females, sex differences are present in how these neural systems are organized, activated and connected with the rest of the brain, and these are postulated to underlie sex differences in the ...
The Atribacterota are widely distributed in the subsurface biosphere. Recently, the first Atribacterota isolate was described and the number of Atribacterota genome sequences retrieved from environmental samples has increased significantly; however, thei
renewable technologies is now important. Unlike fossil fuels, which take millions of years to form, at present usage rates, the fossil fuel era will last only approximately 400 years [84]. Investing in renewables is thus crucial, as future generations will witness the end of finite fossil ...
Among multiple genes aberrantly activated in cancers, invariably, there is a group related to the capacity of cell to self-renewal. Some of these genes are related to the normal process of development, including the establishment of a germline. This grou
Sutherlandia frutescens (L.) R. Br is endemic to Southern Africa where it has been traditionally used for cancer and diabetes. In recent times it has been marketed for its reputed (but not proven) anticancer, antidiabetic and anti-HIV properties. Little
Aedes albopictus is the secondary vector for dengue virus (DENV) in the Philippines, and also harbors chikungunya (CHIKV) and Zika (ZIKV) viruses. This study aimed to determine the minimum infection rates (MIRs) of CHIKV, DENV serotypes, and ZIKV in Ae.
Taxa with more than 1% of the inventoried plants belonged to 18 families, while those with less belonged to 28 other families Full size image According to the life form of the inventoried taxa, almost two-thirds of the plants correspond to herbs (63.72%, including one palm and one cactus)...
While strategies such as chemotherapy and immunotherapy have become the first-line standard therapies for patients with advanced or metastatic cancer, acquired resistance is still inevitable in most cases. The introduction of antibody‒drug conjugates (ADCs) provides a novel alternative. ADCs are a ne...