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The previous curation system for G2P relied on experienced clinical geneticists and scientists making expert judgements to form LGMDE threads. This was based on careful review of the primary literature and manual population of the data fields contained within G2P [2]. The process was not standar...
IRES has been identified as the primary form of resistance to mTOR inhibitors. EPZ015666, the other inhibitor of PRMT5, can inhibit the PRMT5 mediated SDMA methylation of hnRNP A1 in gliomas. This can inhibit the activation of related proteins mediated by IRES and reverse the resistance of ...
Cabbage Fusarium wilt (CFW) is a devastating disease caused by the soil-borne fungus Fusarium oxysporum f. sp. conglutinans (Foc). One of the optimal measures for managing CFW is the employment of tolerant/resistant cabbage varieties. However, the interplay between plant genotypes and the pathog...
Additional tests of statistical significance at 0.05 level in form of deviance tests of nested multivariate models were conducted. Nullmodels that included covariates only were first compared to models including AQ (first comparison), and this model was compared to an additional model containing TAS ...
Parents of study participants signed an Informed consent form. For scRNA-seq, TMJC tissue was isolated by surgical excision. The entire mandible, including the mandibular body and TMJ (condyle, joint capsule, joint disc, part of fibrous ligament and temporo-articular fossa), was isolated along ...
The life cycle of the fungus starts with a three-celled conidium adhering to the leaf surface and undergoing various morphological changes to form a dome-shaped appressorium (Talbot 2003). A turgor pressure of 8 MPa is built up inside the appressorium that is translated into a mechanical ...
CET has functioned in advisory boards of Roche, received non-financial support in the form of research consumables from ADxNeurosciences and Euroimmun, performed contract research, or received grants from Probiodrug, Biogen, Esai, Toyama, Janssen prevention center, Boehringer, AxonNeurosciences, EIP ...
TCs in cluster 17(70) was largely derived from embryos (CFT to CFW; Figure 3) and was annotated by GOs for cell cycle, which is reasonable given the active cell division found in embryos. TCs in cluster 65(70), with a prominent P-value for apoptosis (10-5), originated from ...
Jutten RJ, Peeters CFW, Leijdesdorff SMJ, Visser PJ, Maier AB, Terwee CB, et al. Detecting functional decline from normal aging to dementia: development and validation of a short version of the Amsterdam IADL questionnaire. Alzheimers Dement (Amst). 2017;8:26–35. Article Google Scholar ...