Currently, commercial software is available in the form of RapidPlan (version 13.6, Varian Oncology Systems, Palo Alto, CA, USA) [7,8,9]. A knowledge-based planning (KBP) model is generated using a previous, clinically approved treatment plan data-based regression analysis as the dose-volume...
In its simplest form, the LEWIS rule demands that molecules consisting of main group elements, especially carbon, nitrogen and oxygen, share electrons in a way that all atoms have completely filled s, p-valence shells ('octet rule'). However, free radicals such as 5-hydroxy-2,2-dimethyl-1...
The experience of former Communist countries endeavoring to parlay a vaunted but deeply troubled science and education system into a twenty-first-century innovation economy not only highlights some of the most serious limitations of Soviet-style systems, but also offers insights regarding the Triple He...
The Spacecraft Assembly Facility (SAF) at the NASA’s Jet Propulsion Laboratory is the primary cleanroom facility used in the construction of some of the planetary protection (PP)-sensitive missions developed by NASA, including the Mars 2020 Perseverance
Metabolic engineering has been enabling development of high performance microbial strains for the efficient production of natural and non-natural compounds from renewable non-food biomass. Even though microbial production of various chemicals has successfully been conducted and commercialized, there are still...
A particular type of network is gene regulatory networks (GRNs) that are comprised of regulators and their target genes. One type of regulators is transcription factors (TFs), regulatory proteins that bind to DNA to activate or repress gene transcription. TFs often form complexes that act ...
formins. This section provides brief overviews of the ways ABI1 regulates actin cytoskeleton machineries. ARP2/3 complexes ARP2/3 is activated by nucleation promoting factors such as the WAVE regulatory complex (WRC), a pentameric protein complex comprising ABI1, WAVE2, SRA1/CYFIP1, BRK1, ...
fullyimplementedeitherinsomeorallareasoftheirAswiththedatasubmittedbyalmost1,700hospitalsorganization.in2004,wewillusetheaggregatefindingstoncurriculaandothermeansofsupporttoassistyouinAswithourpastassessments,manykeynationalenhancingmedicationsafety.Additionally,wenorganizationshaveendorsedthe2011ISMPtocomparetheaggregate...
Early preclinical evidence provided the rationale for programmed cell death 1 (PD-1) and programmed death ligand 1 (PD-L1) blockade as a potential form of cancer immunotherapy given that activation of the PD-1/PD-L1 axis putatively served as a mechanism for tumor evasion of host tumor antigen...
However, this weakness has also a positive consequence in the form of decreased false positive rate. Furthermore, the MSD was defined in a way that allows implementation even in case of complex linear models or contrasts, thus allowing for a greater flexibility....