Avian coccidiosis, caused by the protozoan Eimeria, leads to significant economic losses for the poultry industry. In this study, bacteriophages that specifically bind to the calcium-binding protein (EtCab) of Eimeria tenella were selected using a biopan
Dietary depletion of bovine milk exosomes (BMEs) caused a variety of phenotypes in mice including a moderate loss of grip strength, an increase in the severity of symptoms of inflammatory bowel disease, a decrease in postnatal survival and changes in bacterial communities in the ceca [17,18,19...
The aggregation of the “sticky” form, amyloid-β42, into fibrillar structures has been established as one of the mechanisms leading to all known clinical symptoms of Alzheimer’s disease. Consequently, we decided to investigate the role of PSEN1 in neuronal cell death in AD. NeuroDNet tool ...
Our results suggest that wt SIP supports the ubiquitination of exon 1 wt HTT and mHTT, downregulates their protein levels, and consequently inhibits mHTT aggregation. Moreover, SIP mutants that form stable dimers exhibit only residual activity toward HTT ubiquitination and the lesser protection of ...
c The combination of miR-194 and miR-195. At the cut-off value of 0.432, the sensitivity for combined form was 83.33% and the specificity was 86.67%, with an AUC of 0.845 (95% CI = 0.736–0.954) Full size image Discussion CC is a genetic and pathologic condition in which ...
In the recessive form of CCD, MmD, there is a depletion of the RyR1 protein [158]. Although RyR1 is a simple transmembrane protein (homotetrameric), the variation in symptomology in RYR1-RM suggests there is more to this protein and its function, including modifying factors [83, 158]. ...
The human gastrointestinal tract harbors complex and diverse microbes that act as a key factor in maintaining the homeostasis of the intestinal microenvironment [1]. It is estimated that approximately 1013–1014 bacterial cells from more than 1000 different species are present in gut, which form a ...
; however, the proportion of each component in the adult bird food was adjusted to improve digestion and nutrient absorption. Moreover, the baby bird feed was administered in powdered form while the adult bird feed was granular. Fig. 8 Overview of the study design and sample collection Full ...
). Retinoschisin (RS1) is a secreted protein that can form an octamer, and its functions are related to cell adhesion and maintenance of retinal structure integrity [9, 10]. However, the molecular mechanism of RS1 remains elusive. Different forms of mutation in the RS1...
The resulting electrochemical proton gradient forms the basis of the ψmt and is utilized to generate chemical energy in the form of ATP. This ψmt is also one of the crucial factors responsible for Ca2+ uptake. Ca2+ can freely cross the OMM but in order to enter the matrix it must ...