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e Visualization of TLS-like domain detection of SpaDo and other methods (BayesSpace, SEDR, SpaGCN, Scanpy, and Seurat v4) on 4 RCC spatial transcriptomic datasets Full size image The spatial domains detected by SpaDo form a multi-resolution schema hierarchically, enabling the characterization of...
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samples. However, the samples used for the RNA-seq analysis are usually prepared in the form of bulk tissues which might consist of various types of cells. Such a bulk-tissue RNA-seq approach measures only the average gene expression profiles (GEP) of various cell types contained in a ...
RNA profiling technologies at single-cell resolutions, including single-cell and single-nuclei RNA sequencing (scRNA-seq and snRNA-seq, scnRNA-seq for short), can help characterize the composition of tissues and reveal cells that influence key functions in both healthy and disease tissues. However...
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In the ideal intensive care unit (ICU) of the future, all patients are free from delirium, a syndrome of brain dysfunction frequently observed in critical illness and associated with worse ICU-related outcomes and long-term cognitive impairment. Although screening for delirium requires limited time ...