the microenvironment is often species-specific or tumor-specific. Second, in a neoplasm with low growth-rate (for example, indolent/low-grade/chronic tumor; premalignant neoplasms), the development phase of the neoplasm may exceed the lifetime of a mouse. More...
Physical activity was measured using the International Physical Activity Questionnaire Short Form (IPAQ-S). The scale included seven questions that synthesized three types of physical activity: walking, moderate-intensity, and high-intensity [33]. Different intensities of physical activity correspond to ...
The hamster Mesocricetus auratus is a susceptible model for the characterization of the disease, since infection of hamsters with L. infantum reproduces the clinical and pathological features of human VL. In this context, it provides a unique opportunity to study VL in its active form. The main...
11. One of the crucial elements of our constitutional vision is to make a decisive break from the unchecked abuse of State power and resources that was virtually institutionalised during the colonial era and the first 20 years of our independence. To achieve this goal, we adopted accountability...
For endosomes, Meth exposure upregulated Rab5 expression and its guanine-nucleotide exchange factor (GEF) (immature endosome), with a commensurate decreased active form of Rab7 (Rab7-GTP) and impeded the binding of Rab7 to CCZ1 (mature endosome); for autophagosomes, Meth treatment elicited a ...
Briefly, PS was dissolved in chloroform and dried under a vacuum to form a thin layer. DPBS was added to re-hydrate PS, and the liposomes were formed by sonication on ice until the solution became translucent. Octet Red 96 instrument (Fortebio) was used in the bio-layer interferometry (...
These results indicate that the N terminus of ATG4D may have an autoinhibitory effect as its removal increases proteolytic activity, and that ΔN63 ATG4D is likely the active form of ATG4D in cells [Citation21,Citation33,Citation34]. Mammalian cell line studies provide further insight into the...
Moreover, the inhibition of tumor growth by inducing p53/SIRT6/PARP1-dependent parthanatos was further verified in the xenograft mouse model. Results For the first time, we identified that inhibiting AKT triggered parthanatos, a new form of regulated cell death, leading to colon cancer growth ...
(e.g., fixed or individualized formula, patent proprietary formula), which may have been administered alone or in combination with other interventions of conventional Western Medicine (WM) or CAM. No limitation on their formulation, preparation, dosage, dosage form or route of administration. The ...
These patients have CNS involvement, which manifests mainly as progressive cognitive impairment, with a short life expectancy, and often die from severe respiratory disease or cardiac disease before the age of 20 years. In contrast, the mild form has a relatively late onset age, generally delayed...