AD-HSP is the predominant form of the disease, accounting for 43–80% of cases [3, 7,8,9,10,11]. Spastic paraplegia type 4 (SPG4) is the most common type of AD-HSP and is caused by a pathogenic variant in SPAST. Most HSP-SPAST patients are clinically characterized as pure HSPs...
Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060–72. https://doi.org/10.1016/j.cell.2012.03.042. Article CAS PubMed PubMed Central Google Scholar Conrad M, Pratt DA. The chemical basis of ferroptosis. Nat Chem Biol. 2019;15:1137–47. https://doi....
Colony morphology was examined for evidence of contamination and colonies were re-tested for the presence of form-I coxL. This process was repeated until pure cultures were obtained (2 × each). Two isolates were further characterised in this study and named Cupriavidus ulmosensis CV2T and...
Collectively, FAs from exogenous uptake and generation form de novo synthesis make up the cellular FA pool. ACAT, acetyl-CoA acetyltransferase; ACLY, ATP-citrate lyase; ACSS2, acetyl-CoA synthetase 2; ACC1, acetyl-CoA carboxylases 1; ALA, α-linolenic acid; ELOVL, elongation of very long ...
Redox active transition metals such as iron and copper are biologically essential, but are also acutely and chronically toxic in the lungs by virtue of their ability to form insoluble aggregates (e.g. ferruginous bodies) and to catalyze free radical reactions that cause oxidative stress and perman...
Hegde RS, Mastrianni JA, Scott MR, DeFea KA, Tremblay P, Torchia M, DeArmond SJ, Prusiner SB, Lingappa VR: A transmembrane form of the prion protein in neurodegenerative disease. Science. 1998, 279: 827-834. 10.1126/science.279.5352.827. Article CAS PubMed Google Scholar Govaerts C,...
The literature has shown that acetyl-CoA (Ac-CoA) from FAO, on the one hand, supplies energy for the TCA cycle; on the other hand, it shuttles to the cytoplasm outside mitochondria in the form of citric acid and is decomposed again into Ac-CoA, and its biological function in the ...
The inflammatory responses from synovial fibroblasts and macrophages and the mitochondrial dysfunction in chondrocytes lead to oxidative stress, disrupt extracellular matrix (ECM) homeostasis, and accelerate the deterioration process of articular cartilage in osteoarthritis (OA). In recent years, it has been...
Microbiome alterations have been associated with depression, and fecal transfer of depressed patients’ microbiomes is sufficient to enhance despair behaviors in rodents. Yet little is known about the potential mechanisms, whereby microbes modulate depre
[4,5]. Ferroptosis is a form of iron-dependent programmed cell death that involves the processes such as accumulation of intracellular iron, depletion of antioxidant defenses, and lipid peroxidation [6,7]. The management of iron ions, predominantly in the form of redox-active Fe2+, plays a ...