Antiquitin is involved in the oxidation of lysine, and deficiency of this enzyme leads to pathological accumulation of α-AASA, P6C, and piperidic acid. In contrast, the accumulation of P6C can react with PLP to form a Knoevenagel condensate, which inactivates PLP and interferes with the ...
Protein modeling is a computational prediction of the protein’s three-dimensional structure to understand its function. This can help to reveal the host viral proteins interaction, identifying the active sites that guide in designing inhibitors to block the replication of the virus [85]. Also, it...
Fibroblastic reticular cells (FRCs) play a pivotal role in the structural and functional integrity of LN [32]. As specialized fibroblasts, they form a scaffold that defines the microenvironment within LN [33]. This framework supports the distinct niches for immune cells, facilitating efficient immun...
Globally, cancer incidence and death are rising, with lung cancer being the most commonly diagnosed form of cancer (11.6% of the total cases). In the United States, in 2022, there are expected to be ~ 236,740 new lung cancer cases, with ~ 130,180 human demise [1]. Lung can...
Using the cell surface markers Epithelial Specific Antigen (ESA+), CD44+, and CD24−, populations of stem-cell-like cells in breast cancer can be identified [11,102]. It is shown that in the xenograft mouse model, as few as 200 cells of these cells can form tumors [11]. In additio...
The second stage of biotin synthesis is a highly conserved process starting from the precursor pimelate moiety, sequentially catalyzed by the enzymes BioF/BioA/BioD/BioB. The pimelate moiety contributes two carbon atoms to form its rings and five carbon atoms to from the valeric acid side ...
with each parameter representing the difference between having no problems and having a certain level of problems on a particular dimension, were estimated on the data. The cTTO and DCE data were modelled in isolation as well as jointly. Details on the functional form of these models can be ...
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To explore the potential for SplicerAV to identify novel changes in mRNA isform abundance in breast cancer, we applied SplicerAV to several publicly available, archival Affymetrix HG-U133 plus 2.0 datasets. SplicerAV predicts oncogene induced changes in alternative processing of splicing factors ...
such as food digestion by enzymes, nutrient absorption, and the synthesis and storage of various macromolecules. The intestine includes approximately 20 cells arranged to form a tube with a central lumen. The surface of intestinal cells carries numerous microvilli to increase the absorption surface [...