In recent years, there has been a growing interest in drug combination therapy as a way to improve the effectiveness of tumor treatment and reduce drug resistance that can occur with long-term single drug use. Researchers are increasingly exploring the combination of NO with other treatments such ...
3). Using this approach, a total of 23 sequences encoding PGRPs were confirmed (representing 18 genes and 5 isoforms) (Additional file 2). Phylogenetic analysis showed that these sequences separated into 4 distinct clades (Additional file 3). The majority (15 genes) represented short-form ...
l-asparaginase is a member of the amidohydrolase family and it is the first enzyme approved for cancer therapy. L-asparaginases has been produced in E. coli and Erwinia chrysanthemi in its native and recombinant form for treating acute lymphocytic leukemia [11]. Both l-lysine and l-arginine ...
Dicer, a RNase III endoribonuclease, can cleave long double-stranded RNA (dsRNA) or stem-loop-stem structured pre-miRNA to form mature miRNAs in the cytoplasm. Interestingly, we found that down-regulated Dicer expression was mainly located in the nucleus of ICC cells (Fig. 1a-b, Fig. 2b ...
The first two enzymatic steps of monoterpene indole alkaloid (MIA) biosynthetic pathway are catalysed by strictosidine synthase (STR) that condensates tryptamine and secologanin to form strictosidine and by strictosidine β-D-glucosidase (SGD) that subsequently hydrolyses the glucose moiety of strictosidin...
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Initially, white fibrous roots (FRs) develop and some of these subsequently develop into SRs. Depending on the number of FRs induced to form SRs, sweetpotato plants will yield either a high (4 to 8 per plant) or low number of SRs that may even be reduced to one very large SR per ...
While C-REase fusions have not previously been characterized, other types of REase fusions have. One class, for example, involves natural and synthetic fusions of the REase and MTase polypeptides [53–56]. This ability to form a variety of active fusions illustrates the remarkable flexibility and...
The luciferase reporter was strongly stimulated by WT but not by the mutant form of Runx2 (Figure 1E). As shown in Figure 1F, Runx2 also stimulated transcription of its endogenous target genes Bone Sialoprotein (BSP) [29] and Matrix Metalloprotease-9 (MMP9) [28]. These genes were not ...
Rabbit haemorrhagic disease virus (RHDV) is a highly virulent calicivirus, first described in domestic rabbits in China in 1984. RHDV appears to be a mutant form of a benign virus that existed in Europe long before the first outbreak. In the Iberian Peni