Two strategies have been proposed to overcome immune suppression: the disruption of TGF-β receptors on CAR-T cells and the engineering of CAR-T cells to express a dominant-negative form of the TGFβ receptor (TGFβRIIDN) into the CAR-T cell construct which allows the CAR-T cells to ...
For instance, a personalized mRNA vaccine, autogene cevumeran (BNT122), has been developed for pancreatic cancer treatment in a phase I clinical trial [78]. The vaccine operates by using mRNA to express 20 neoantigens derived from patients with pancreatic ductal adenocarcinoma (PDAC), ...
Nanotechnology holds immense promise in revolutionising healthcare, offering unprecedented opportunities in diagnostics, drug delivery, cancer therapy, and combating infectious diseases. This review explores the multifaceted landscape of nanotechnology i
In recent years, LNPs have been successfully employed for clinical applications and trials of various RNA therapeutics, such as siRNA, mRNA, and CRISPR–Cas9, to treat diseases like cancer, infections, and genetic disorders [10]. Notably, in 2020, LNP-encapsulated mRNA vaccines of BNT162b2 and...
Data collection was performed through an anonymized electronic case report form managed by the REDCap electronic data capture tool hosted on a secure server by the Swiss Society of Intensive Care Medicine. Data were collected on the day of ICU admission, and on days 1, 2, 3, 5 and 7, ...
The safety of the participant will always be the primary consideration in making this decision. The reason for unblinding and the date it occurs must be documented in the source documentation and case report form (CRF). The study-specific IRT reference manual and investigational product manual ...
aThe available generic administrative forms include a Non-Disclosure Agreement, an Acknowledgement of Receipt form and an Informed Consent form 可利用的普通行政形式包括保密协定,回执形式和一个知会同意形式[translate] a(2nd COPY TO SUBMIT WITH UN-PRICED BID) (第2复制递交以无定价出价)[translate] ...
The seed coat is derived from the outer and inner integuments of the ovule [4]. Proanthocyanidins (PAs), an end products of flavonoid biosynthesis, are synthesized and accumulated in inner integument during the seed development [5]. The innermost cells of the outer integument form a palisade...
The Moderna mRNA-1273 and Pfizer-BioNTech BNT162B2 COVID-19 vaccines are the most eminent examples of mRNA vaccine employment in infectious diseases, contributing to the plummet of COVID-19’s burden worldwide [7]. This successful experience paved the way for the future development of other mR...
Those fear appeals which are fremed in the form of perceived susceptibility or risk and perceived severity were predictors of behavioral intention to perform COVID-19 prevention behaviors [21, 22]. For more than five decades, the Health Belief Model (HBM) has been a widely used conceptual ...