Firstly discovered in porcine brain, BNP is stored in atrial granule with ANP, but not in granule in ventricle [14]. BNP is mainly secreted by normal atrium [15]. However, as a hallmark for maladaptive remodeling of left ventricle (LV), BNP is mainly secreted in ventricle when LV function...
Garadacimab (CSL312) is an FDA-approved fully human monoclonal IgG4 antibody against FXIIa. It is an affinity-matured, recombinant variant of the monoclonal antibody 3F7 which was shown to reduce the severity of potentially life-threatening abdominal aortic aneurysms, inhibit the development of at...
However, participants from LICs (25.4%) were more likely than those from MICs (19.3%) and HICs (9.4%) to report an improved health status, whereas participants from HIC (19.8%) were more likely than those form LICs (7.5%) and MICs (17.6%) to report a deteriorated health status. ...
For exploring the functional aspects of the genes that harbor AS, the 142 ASSETs were classified within the biological process categories. Using BinGO tools [31], 11 categories revealed a statistically significant enrichment of genes (Table 4) and are represented in a hierarchical form in Figure ...
. They have been shown to suppress the activity of TEs in plants and animals. In animal germline cells, piRNAs of 24 to 35 nt are produced and loaded onto germline-specific Argonaute proteins (termed PIWI proteins) to form piRNA-induced silencing complexes (piRISCs). Genetic analyses of...
Jones RJ, Schreiber BMN, McNeil KJ, Brenner ML, Faxon G. Cytokinin levels and oxidase activity during maize kernel development. In: Kaminek M, Mok BWS, Zazimalova E, editors. Pysiology and biochemistry of Cytokinins in plants. The Hague, The Netherlands: SPB Academic Publishing; 1992. p...
Increased heterogeneity and compartmentalization of the hyphal network resulting in empty, cryptically growing and conidiating compartments implies an ordered form of fungal cell death ensuring self-propagation to survive life-threatening starvation conditions. In A. nidulans it was shown that disruption ...
Increased heterogeneity and compartmentalization of the hyphal network resulting in empty, cryptically growing and conidiating compartments implies an ordered form of fungal cell death ensuring self-propagation to survive life-threatening starvation conditions. In A. nidulans it was shown that disruption ...
The prothoracic gland (PG), the principal steroidogenic organ of insects, has been proposed as a model for steroid hormone biosynthesis and regulation. To validate the robustness of the model, we present an analysis of accumulated transcriptomic data fro
TSC, characterized by benign hamartomas in multiple organs, is caused by mutations in either of the two tumor suppressor genes encoding hamartin (TSC1) and tuberin (TSC2). Features of ASD are present in 30 to 60% of individuals with TSC [5]. Hamartin and tuberin form a complex that ...