For exploring the functional aspects of the genes that harbor AS, the 142 ASSETs were classified within the biological process categories. Using BinGO tools [31], 11 categories revealed a statistically significant enrichment of genes (Table 4) and are represented in a hierarchical form in Figure ...
Autism spectrum disorder (ASD) is reported in 30 to 60% of patients with tuberous sclerosis complex (TSC) but shared genetic mechanisms that exist between TSC-associated ASD and idiopathic ASD have yet to be determined. Through the small G-protein Rheb,
Although the molecular mechanism underlying this form of cell death is not fully elucidated, it shares common signaling pathways with canonical autophagy. Key regulators driving this process include conserved ubiquitin-fold proteins [e.g., autophagy-related (ATG) proteins]. Among them, the ULK1/2 ...
Garadacimab (CSL312) is an FDA-approved fully human monoclonal IgG4 antibody against FXIIa. It is an affinity-matured, recombinant variant of the monoclonal antibody 3F7 which was shown to reduce the severity of potentially life-threatening abdominal aortic aneurysms, inhibit the development of at...
form o Fig. 1 A diagrammatic depiction of periodontitis. Gingivitis is distinguished by the presence of inflamed, red, and oozing gums that encircle the teeth. Although periodontal disease exhibits similar symptoms, it additionally manifests as bone loss. A viscous substance called plaque, which is...
An industrial approach to protein production demands maximization of cloned gene expression, balanced with the recombinant host’s viability. Expression of toxic genes from thermophiles poses particular difficulties due to high GC content, mRNA secondary
Increased heterogeneity and compartmentalization of the hyphal network resulting in empty, cryptically growing and conidiating compartments implies an ordered form of fungal cell death ensuring self-propagation to survive life-threatening starvation conditions. In A. nidulans it was shown that disruption ...
However, participants from LICs (25.4%) were more likely than those from MICs (19.3%) and HICs (9.4%) to report an improved health status, whereas participants from HIC (19.8%) were more likely than those form LICs (7.5%) and MICs (17.6%) to report a deteriorated health status. ...
Spiders produce silk naturally in the form of fibers. However, silk produced through recombinant techniques involves the extraction of spider silk proteins in the form of powder. This technique allows for the combination of spider silk proteins with various materials to create fibers with different me...
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