2]. In the last years numerous methods have been developed and applied to reconstruct the structure and dynamic rules of gene-regulatory networks from different high-throughput data sources, mainly microarray based gene expression
Cardiopulmonary resuscitation-associated lung edema (CRALE) is a specific form of lung damage that has been recently described both experimentally and clinically after cardiac arrest and CPR [5, 6]. CRALE is characterized by increased lung weight and density with reduced aeration, as measured by ...
The ISGA genome annotation, promoter and TSS mapping, combined with proteomics data support expression of an alternative, shorter form of RegR. Table 1 Proteomics and dRNA-seq evidence for new ORFs and longer or shorter proteins than originally annotated Full size table Fig. 3 Combined ...
To confirm ECFC phenotype, cells were assessed for their ability to form tubes using in vitro tube formation assay. For the tube formation assay, 200 µl of growth factor reduced Matrigel (BD) was added to the bottom of a 24 well plate and allowed to set for 1 h in a 37 °C incub...
The majority of RYR1 mutations associated with MHS or CCD described to date were dominant mutations; homozygosity or heterozygosity for RYR1 mutations has been previously documented in association with MHS [66, 67] and have been recently reported in a severe form of CCD presenting with a foetal ...
High-level standardization, common exchange mechanisms, interfaces and protocols, and semantic interoperability form the foundation for widespread adoption of the FAIR principles [9] in health research. Data that are shared collaboratively in such health-related cloud projects are now largely standardized ...
(PEG) copolymers are one of the most popular vehicles for drug delivery. The NPs can be functionalized with suitable fluorescent markers, antibodies against tumoural marker, gene delivery agents and drug molecules coated with a form of PEG. The antibody is using a long linking molecule that ...
Activation of mast cells (MCs) can be achieved by the high-affinity receptor for IgE (FcεRI) as well as by additional receptors such as the lipopolysaccharide (LPS) receptor and the receptor tyrosine kinase Kit (stem cell factor [SCF] receptor). Thus, pharmacological interventions which stabi...
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Intervention: Hydromorphone in any form. Comparator: Placebo, substitute opioid, hydromorphone (different route and dose of administration), or another active control. Outcomes: Cancer pain intensity, additional analgesic consumption, breakthrough pain, quality of life, and adverse events. Study design:...