Biochemical recurrence (BCR) occurs in 20%–40% of men with prostate cancer (PCa) who undergo radical prostatectomy. Predicting which patients will experience BCR in advance helps in formulating more targeted prostatectomy procedures. However, current preoperative recurrence prediction mainly relies on th...
Human iPSCs' derivation and use in clinical studies are transforming medicine. Yet, there is a high cost and long waiting time associated with autologous iPS-based cellular therapy, and the genetic engineering of hypo-immunogenic iPS cell lines is hampered with numerous hurdles. Therefore, it is...
Exosomes which are membrane vesicles released by cells have gained significant interest in the field of cancer therapy as a novel means of intercellular communication. Their role in immune activation and their pathophysiological functions in cancer therapy have been recognized. Exosomes carry diverse bioac...
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Hook effect of PROTAC The bifunctional molecule (“B”) interacts with its two substrates (“A” and “C”), forming “A-B-C” ternary complex to exert its biological functions. When the concentration of “B” exceeds a certain range, “B” prefers to form “A-B” and “B-C” bina...
Thus, there is a distinct need for a standardized system of technologies and tools for working efficiently with computer representations of biological entities, data, information, probabilities, and statistical models - both locally and on the network. Great efforts are indeed being made in this dire...
(PIK3CD, MIM 602839) shared by the three affected siblings and inherited from their apparently healthy father. This variant was reported previously to cause an autosomal dominant form of immunodeficiency [55]. To assess possible mosaicism in the father, we calculated the ratio of variant to ...
2023). This particular form of breast cancer is widely regarded as one of the most hostile. Due to the insufficient expression of ER, PR and HER2 in TNBC tumors, patients derive limited benefit from existing endocrine and targeted therapies (Derakhshan and Reis-Filho 2022). As a result, ...
development of the organism. After the organism develops into its adult form, cell differentiation is minimal and most of the regulatory interactions that are involved in these regulatory pathways are lost. However, the dynamic rewiring of the gene regulatory networks for other cellular functions is ...
Regular antisense RNA refers to the most basic form of asRNA, i.e. an unmodified RNA molecule of the exact reverse and complement sequence of the target RNA. To obtain this, a segment of the target gene can be amplified and cloned into a vector in an antisense orientation downstream from ...