(2b) Nucleoid-phagy is a form of autophagy that selectively degrades cytosolic mtDNA bound to the mitochondrial transcription factor A (TFAM). It depends on the LC3-interacting region 2 (LIR2) motif of TFAM that
Alzheimer’s disease (AD), the most prevalent and progressive form of senile dementia, affects an estimated 6.9 million Americans aged 65 and older [1]. It is characterized by the accumulation of amyloid beta-protein (Aβ) deposits and abnormal tau protein aggregates in the brain [18,51]. ...
involving CHDs that have undergone clinical studies for the evaluation of their anticancer efficacy and were used in the same form as in the clinical studies, using multiple doses, and having positive control(s); chemical analyses involving CHDs that have undergone clinical ...
form of abbreviations.nlp.add_pipe("scispacy_linker",config={"resolve_abbreviations":True,"linker_name":"umls"})doc=nlp("Spinal and bulbar muscular atrophy (SBMA) is an\inherited motor neuron disease caused by the expansion\of a polyglutamine tract within the androgen receptor (AR).\SBMA can...
Molecular functions of A-to-I editing ADARs deaminate adenosine in dsRNA or the A-form helix (DNA: RNA hybrid) [46,47,48]. The introduction of non-canonical base pairs into the dsRNA structure increases complexity, which actually affects the efficiency of adenosine editing (Fig. 2). The tw...
For analysis of tumor infiltrating lymphocytes, tumors were collected on day 16 post-implantation and processed to form single-cell suspensions as previously described.Citation39 The cells were then stained for analysis by flow cytometry as described above. Identification of SIINFEKL bound to H-2Kb...
of biomedical literature. Biomedical relation classification has seen significant improvement from the application of advanced machine learning techniques on free-form text from large collections of scholarly publications. Despite this improvement, the reliance on large chunks of raw text makes these ...
To further analyze the mechanism underlying dtCAR-NK92 cell killing, we plan to clarify which inflammatory caspase activates GSDM family members and cleaves them to produce its active form, thus triggering dtCAR-NK92 cell-induced pyroptosis. In vivo, dtCAR-NK92 cells significantly controlled H...
Single nucleotide polymorphism (SNP), a common form of genetic variation, is caused by the transition, transversion, insertion, or deletion of individual bases. Expression quantitative trait loci (eQTL) analysis can profile genetic variations (especially SNP) that affect gene expression, offering enhan...
(anti-SARS-CoV-2 S2), and VRC01 (anti-HIV-1) were non-NIEAs as negative controls. The infection-enhancing activity of IgG-, F(ab’)2, and Fab-form P10S-1D9 were measured using HEK293T-hACE2 cells(c)and Huh7 cells(d). The experiments were performed twice and one representative...