The outer membranes of mitochondria are thought to be homologous to the outer membranes of Gram negative bacteria, which contain 100's of distinct families of β-barrel membrane proteins (BOMPs) often forming channels for transport of nutrients or drugs. However, only four families of mitochondrial...
As a result, an intrinsically disordered polypeptide can partially or completely fold or misfold and form amyloid-like fibrils, whereas ordered protein can likewise misfold and assemble into a pathogenic fibrillar form (see Figure 2) [14]. Figure 2 The modern understanding of the fate of a ...
Like other proline-rich cell-wall proteins, extensins require hydroxylation of prolines to 4-hydroxyprolines to form the cell wall matrix [72]. Consistent with extensive hydroxylation of extensin, UniTag STCa-542 representing a prolyl 4-hydroxylase alpha subunit-like protein belonged to the most...
Compared to those tissue stem cells existing in adult tissues or organs, embryonic stem cells (ESCs) derived from the inner cell mass of blastocysts are pluripotent which can form three germ layers (ectoderm, mesoderm, and endoderm) (Thomson et al., 1998). In addition to ESCs, human-induced...
This structure is the source of pluripotent cells. Pluripotent stem cells (PSCs) form cells of all germ layers but not extraembryonic structures, such as the placenta. Embryonic stem cells (ESCs) are an example. ESCs are derived from the inner cell mass of preimplantation embryos. Another ...
If I want to preview a full screen image of a (second) window in the thumbnail, I must click on the thumbnail. To get back to where I started, I must find and click the thumbnail for the original window on which I was working. It's a minor inconvenience, but since I know (from...
(i.e. a PSV) rather than genuine SNP variation at a single unique genomic location. For libraries 1 - 5, equal amounts of individual genomic DNA was multiplexed to form pools of total 15 μg and, for library 6.5 μg genomic DNA from the haploid sample was used. These pools were ...
Node.js' package ecosystem, npm, is the largest ecosystem of open source libraries in the world. 以前我们总是喜欢拿异步说事儿,现在我们拿 Node.js 的强大的生态来炫耀 大事儿记 下面介绍点 Node.js 的大事儿记 企业级 2014年 nearformNODE.JS 为什么会成为企业中的首选技术 ...
(a, b, and c). Tender, red Sweet's syndrome lesions in a woman with the classical form of the dermatosis. A closer view of the Sweet's syndrome lesions from the woman in Figure 1. The skin lesions improved rapidly after corticosteroid therapy was initiated. There is an erythematous plaqu...
The traditional view of protein aggregation as being strictly disease-related has been challenged by many examples of cellular aggregates that regulate beneficial biological functions. When coupled with the emerging view that many regulatory proteins undergo phase separation to form dynamic cellular compartm...