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Alzheimer’s disease (AD) is the leading cause of dementia, characterized by a complex pathogenesis that complicates the development of effective treatments. Natural products are promising multitarget agents because of their ability to interact with mult
Combinations of LLP peptides appear to act cooperatively to increase the whole cell conductance of Xenopus oocyte plasma membranes. Taken together, these results suggest that the C-terminal domains of HIV-1 Env proteins may form an ion channel, or viroporin, that is capable of conducting Na+ ...
The homotetramer structure for AQP4 is consistent with the structure of other AQPs [20, 25]. While AQP4 cannot associate with other AQPs, it can form heterotetramers of M1 and M23 [20]. The importance of the M1:M23 isoform ratio to function in situ is not known, but in cultured ep...
Next, PBG undergoes a polymerization reaction triggered by porphobilinogen deaminase (PBGD) to form an unstable linear tetrapyrrole 1-hydroxymethylbilane (HMB), which is utilized as a substrate by uroporphyrinogen III synthase (UROS) and cyclized to produce uroporphyrinogen III (UPG III). In ...
Immunoglobulinic amyloidosis, also referred to as AL or “primary” amyloidosis, in which fibrils are made up of a monoclonal immunoglobulin (Ig) light chain (LC), is the most common and the most severe form of amyloidosis. AL amyloidosis is usually a systemic disease characterized by multiple...
The outer membranes of mitochondria are thought to be homologous to the outer membranes of Gram negative bacteria, which contain 100's of distinct families of β-barrel membrane proteins (BOMPs) often forming channels for transport of nutrients or drugs. However, only four families of mitochondrial...
followed by a period of retardation where some skills fail to develop or do so but behind schedule, a period of regression where some acquired skills are lost, or a period of intrusion where acquired skills are overshadowed by the appearance of behaviors aberrant in form or frequency [2, 3]...
of its unique ability to alter protein structure and function. In pharmaceuticals, L-Citrulline can serve as a precursor for developing therapies targeting cardiovascular diseases or enhancing nitric oxide production [4,5,6]. Citrullination pathways, employed in the production of L-form amino acids,...
Interestingly, the number of neurons was normal to slightly reduced. The intracellular inclusions were distributed bihemispherically in many neurons of nearly all investigated brain regions. A detailed list is provided in Table 2. Most severely affected were the cerebral cortex laminae V and VI, ...