campaign. Saturday night, President Biden condemned the shooting.(Begin VT)JOE BIDEN (President of the United States): There's no place in America for this kind of violence. It's sick. It's sick. It's one of the reasons why we have to unite this country.We cannot allow for this to...
Metformin, a widely prescribed antidiabetic drug, has shown several promising effects for cancer treatment. These effects have been shown to be mediated by dual modulation of the AMPK-mTORC1 axis, where AMPK acts upstream of mTORC1 to decrease its activi
The DEAD-box helicase family member DDX3X (DBX, DDX3) functions in nearly all stages of RNA metabolism and participates in the progression of many diseases, including virus infection, inflammation, intellectual disabilities and cancer. Over two decades, many studies have gradually unveiled the role ...
The number of ligand-receptor pairs between every two cell types was shown in the form of heatmap. The weights/strength of ligand-receptor pairs between every two cell types was shown in the form of circos plot. Deconvolutions of bulk RNA-seq transcriptomics DWLS (Dampened weighted least ...
Statins and COVID-19: the results form the clinical studies The effect of statin use on the severity and prognosis of COVID-19 has been the subject of several meta-analyses (Tab. 2.). A study by Lee et al. involving 10,448 COVID-19 patients investigated the effect of statin administra...
Oxidative stress is supposed to increase lipid accumulation by stimulation of hepatic lipogenesis at transcriptional level. This study was performed to investigate the role of glutathione in the regulation of this process. For that purpose, male rats wer
After intravenous delivery of the adenoviral vector into rats or mice, 95–99% of the encoded protein is produced in the hepatocytes. We observed, as have others, that the early expression levels of the vector encoded protein vary, greatly, within a spec
common way of taking medicine is oral ingestion for internal use but in some ailments, topical application is frequently employed in the form of paste. Decoction of the leaves is administered for dyspepsia, jaundice, and cardiac and respiratory problems and is used as a tonic [82]. The major...
One form of ER stress is known as protein kinase RNA-like ER kinase (PERK)/translation initiation factor eIF2α pathway, which has a role in diabetes and diabetic complications [18]. Under ER stress, glucose regulated protein 78 (GRP78) in the ER was dissociated from PERK and resulted in...
1O). We also examined the expression of APOL1 mRNA in 40 renal cancer tissues and their corresponding noncancerous tissues form The Union hospital and obtained similar results (Fig. 1P)( Supplementary Table S1B). The renal tissues form The First Affiliated Hospital of Anhui Medical University ...