Additionally, NK cells augment the anti-tumor activity of adaptive immune cells via cytokine secretion. However, metabolic interference in the form of lactic acid accumulation within the TME reduces intracellular pH in NK cells, inducing pH-dependent mitochondrial stress and metabolic disruption, ...
Prematurity has also been linked to the severe form of respiratory disease caused by RSV [48, 49]. The clinical significance of RSV infection is further demonstrated by the fact that the median length of hospitalization in children with that disease has been found one day longer in all ...
Surprisingly, the EMPA-REG OUTCOME trial, a long-term, multicenter, randomized, double-blind, placebo-controlled clinical trial, became the beginning of the cardiovascular application of SGLT2i. This study showed that treatment with the SGLT2i (empagliflozin) in diabetic patients with cardiovascular ...
Skin cancer (SC), is one of the most devastating cancers of the present decade, and the fifth commonest form of cancer [1,2,3]. It is further predicted to surpass heart disease as the main cause of mortality and the biggest obstacle to extending life expectancy in the next decades. Acc...
The hPSCs form cell-only aggregates and are cultivated for two to three days (depending on the cell line) in suspension at 80 rpm in STBRs. After 24 h of cultivation, perfusion starts in STBRs, exchanging 1 × reactor volume/day for fresh medium with an increased glucose ...
Extracellular vesicles (EVs) are membranous nanovesicles that are released from cells and participate in a form of intercellular communication. They can transport ‘cargo’, including DNA, RNA, and proteins, between cells [12,13]. Although the presence of pericellular vesicles in mammalian tissues ...
This study was initiated to test short- and long-term effects of V-aCD3Muon cancer in mice with a competent immune system, to potentially make V-aCD3Huan interesting therapy against human cancers. Mice were randomly assigned or grouped based on tumor size for similar means. Treatments and mea...
Radiotherapy for tumors includes two main types of treatment: external and internal radiotherapy [107]. External radiotherapy is still the main form of radiotherapy for liver cancer and can help patients with HCC at various stages. However, external radiotherapy sends rays to the tumor site in the...
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The Cas9 and guide RNAs can be introduced in the form of DNA, RNA/mRNA, or ribonucleoprotein.Citation85,Citation92,Citation103 The delivery methods are usually divided into physical (electroporation and microinjection), viral (lentiviral, adenoviral, and AAV vectors), and non-viral (plasmids, ...