Frail patients were defined as having a CFS of ≥ 5. We also recorded Katz activities of daily living (Katz ADL) [11], with an ADL score ≤ 4 defining disability. Pre-admission cognitive function was assessed using the Short form of Informant Questionnaire on Cognitive Decline in ...
Successful development of agents that improve cognition and behavior in Alzheimer’s disease (AD) is critical to improving the lives of patients manifesting the symptoms of this progressive disorder. There have been no recent approvals of cognitive enhan
Introduction: Enthesitis-related arthritis (ERA) is a category of Juvenile idiopathic arthritis considered to be a form of Juvenile Spondyloarthropathy (jSpA). Tumor necrosis factor (TNF)-blocking strategies have proven effective in the treatment of jSpA1-2. Objectives: To assess effectiveness of an...
We have sought to focus on first episode and recurrent MDD in the present sample. Treatment-resistant depression is currently a clinical criterion that refers to a form of depression which shows significant persistent symptoms despite a series of treatments. If treatment resistance is present at the...
Older adults want to live at home as long as possible, even in the face of circumstances that limit their autonomy. Home care services reflect this emergent preference, allowing older adults to ‘age in place’ in familiar settings rather than receiving
Taurine is a natural amino acid present as free form in many mammalian tissues and in particular in skeletal muscle. Taurine exerts many physiological functions, including membrane stabilization, osmoregulation and cytoprotective effects, antioxidant and anti-inflammatory actions as well as modulation of ...
Distressing symptoms are common in advanced cancer. Medicinal cannabinoids are commonly prescribed for a variety of symptoms. There is little evidence to support their use for most indications in palliative care. This study aims to assess a 1:20 delta-9-
To explore the biological activity of EMD 273063 (hu14.18-IL2), a humanized anti-GD2 monoclonal antibody fused to interleukin-2 (IL2), in patients with unresectable, stage IV cutaneous melanoma as measured by induction of immune activation at the tumor site and in peripheral blood. Methods Nine...
Breast cancer is the most frequently diagnosed form of cancer and the second leading cause of death in Western women [1]. Death, and most of the complications associated with breast cancer, are due to metastasis developing in regional lymph nodes and in distant organs, including bone, lung, ...
There has been considerable interest in using the Adult Social Care Outcomes Toolkit (ASCOT), developed in England, to measure quality-of-life outcomes of long-term care (LTC-QoL) service provision in national and cross-national studies. The aim of this