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Receptor-like proteins (RLPs) are crucial pattern-recognition receptors on the surface of plant cells, which are involved in almost all processes of the plant life cycle. Recently, the evolution of high-throughput sequencing technology has strengthened t
Interest in prostate cancer as a research topic has gradually increased. As a result, a series of innovative treatment strategies have emerged with an in-depth understanding of the disease. Owing to their unique biological characteristics, mesenchymal st
All Flo proteins are glycosylphosphatidylinositol (GPI)-anchored glycoproteins with an identical three-domain structure [49]. Among these proteins, Flo1 acts as a sugar-sensitive cell surface flocculin that utilizes its C-terminal GPI anchor sequence to directly bind to mannose residues on adjacent ...
1F). Of note, CD52, a GPI-anchored glycoprotein that rarely possesses an intracellular signaling domain, is mainly expressed on the cell surface of mature lymphoid cells and acts as a soluble form to suppress T-cell activation [45]. Regardless of stage classification (Fig. S1J), CD52 ...
Glioblastoma (GBM) is a highly invasive and aggressive tumor of the central nervous system that differs from other adult-type diffuse gliomas since it expresses the wild-type form of isocitrate dehydrogenase (IDH) [1]. It shows a diffuse growth pattern, which hinders its complete surgical removal...
Children presenting to hospital with recent or current Plasmodium falciparum malaria are at increased the risk of invasive bacterial disease, largely enteric gram-negative organisms (ENGO), which is associated with increased mortality and recurrent morbidity. Although incompletely understood, the most likel...
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Mast cells are present in limited numbers in normal human synovium, but in rheumatoid arthritis and other inflammatory joint diseases this population can expand to constitute 5% or more of all synovial cells. Recent investigations in a murine model have demonstrated that mast cells can have a criti...