Women present a higher prevalence of PTSD, but PTSD-like models in rodents are usually employed only in males [4], thus ignoring the sex-specific neurobiological substrates. Fear conditioning (FC) is a form of classical conditioning used in research to evaluate fear learning and fear memory [5...
2B). The AlphaFold model provides confidence estimations in the form of predicted local Distance Difference Test (lDDT) scores per residue [33]. The lDDT score is a superposition-free metric ranging from 0 to 100, indicating the fidelity of the protein model to the reference structure [34]. ...
As of 2020, hepatocellular carcinoma (HCC), a form of liver cancer, stood as the third most prominent contributor to global cancer-related mortality. Combining immune checkpoint inhibitors (ICI) with other therapies has shown promising results for treati
Briefly, iPSCs were dissociated with Gentle Cell dissociation reagent and transferred to uncoated flasks in NPC Induction Media to allow for embryoid bodies (EB’s) to form. EBs were cultured for 7 days and then transferred to polyornithine/laminin coated flasks and grown for another 7 days in...
FOP occurs because of gain-of-function mutation in activin A receptor type I/activin-like kinase 2 (ACVR1/ALK2), and over 95% of the typical form of FOP patient population displayed the mutation c.617G > A, p.R206H. However, other mutations which cause FOP seemingly lead to ...
PLGA polymers are attractive drug delivery vehicles, especially in the form of nanoparticles, because of their excellent safety profile and ability to spontaneously degrade in biological systems into lactic acid and glycolic acid (Fig. 1a) [22]. We were interested in utilizing PLGA nanoparticles not...
The external pH environment can change the shape of human RBCs. RBCs form stomatocytes at low pH and schistocytes at high pH [28]. A study showed that high-frequency electric fields can induce the deformation of RBCs. The electrical membrane breakdown could lead to depolarization and hemolys...
modified immune cells are redirected towards tumor cells via chimeric antigen receptors (CARs), which reprogram the patient's T cells to effectively eradicate malignant neoplastic growth [25]. Although CAR is categorized as a form of cell therapy, it exhibits overlapping characteristics with gene ...
ICANS is a form of neurotoxicity that can occur after CAR-T therapy, manifesting as symptoms such as difficulty concentrating, confusion, delirium, aphasia, lethargy, tremors, and seizures [192]. Corticosteroid therapy and tocilizumab are the first-line treatments for ICANS [193]. However, these ...
< 0.001 full size image to corroborate the above findings, we performed gain-of-function experiments involving aav-mediated overexpression of trem2 in liver macrophages in a mouse orthotopic hcc model (supplementary fig. 1 a). the liver/body weight ratios were greater in the aav-trem...